Identification of novel cancer antigens for oral squamous cell carcinoma and research towards clinical application
Project/Area Number |
26463051
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
|
Research Institution | Sapporo Medical University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 口腔癌 / 腫瘍免疫 / 口腔がん |
Outline of Final Research Achievements |
Aiming at establishing a pair of autologous cancer cell line and its CTL for the identification of novel cancer antigen, Sapporo Medical University Hospital Dental Department of Oral Surgery than the biopsy tissue of cheek oral squamous cell carcinoma patient treated In the establishment of a cell line successfully, PBL or TIL of a patient with established cancer cell line was isolated, cultured in AIM-VRMedium supplemented with rI l -2 (50 IU / ml), and irradiated with X rays Mixed culture of autologous cancer cell line and PBL or TIL was repeated, induction of CTL succeeded in establishing pair of autologous cancer cell line and its CTL. Analysis of autologous cancer-specific cytotoxicity mechanism was carried out.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Hypoxia-induced epithelial-mesenchymal transition is regulated by phosphorylation of GSK3-β via PI3 K/Akt signaling in oral squamous cell carcinoma.2016
Author(s)
Kaneko T, Dehari H, Sasaki T, Igarashi T, Ogi K, Okamoto JY, Kawata M, Kobayashi JI, Miyazaki A, Nakamori K, Hiratsuka H.
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Journal Title
Oral Surg Oral Med Oral Pathol Oral Radiol.
Volume: 122(6)
Issue: 6
Pages: 719-730
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A case of surgical treatment of mandibular condylar fracture with facial nerve paralysis.2016
Author(s)
Masato Abe, Akihiro Miyazaki , Mitsuyoshi Nakai , Tomohiro Igarashi , Jun-ichi Kobayashi , Akira Yorozu , Takanori Sasaki , Mayumi Kawata , Hironari Dehari , Kazuhiro Ogi , Hiroyoshi Hiratsuka
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Journal Title
Journal of Oral and Maxillofacial Surgery , Medicine , and Pathology
Volume: 28
Pages: 324-327
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship Between Mandibular Ramus Height and Masticatory Muscle Function in Patients With Unilateral Hemifacial Microsomia.2016
Author(s)
Suzuki N, Miyazaki A, Igarashi T, Dehari H, Kobayashi JI, Miki Y, Ogi K, Nagai I, Sonoda T, Yotsuyanagi T, Hiratsuka H.
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Journal Title
Cleft Palate Craniofac J
Volume: -
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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