| Project/Area Number |
26463059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Matsumoto Dental University (2016)
Niigata University (2014-2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
泉 健次 新潟大学, 医歯学系, 教授 (80242436)
|
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| Co-Investigator(Renkei-kenkyūsha) |
TERASHI HIROTO 神戸大学, 医学研究科, 教授 (80217421)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 移植・再生医療 / 口腔顎顔面再建外科学 / 口腔粘膜 / 上皮幹細胞 |
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| Outline of Final Research Achievements |
We have investigated the application of ex vivo-produced oral mucosa equivalent (EVPOME) and evaluated its ability of oral mucosa regeneration. However, cultivated epithelial cells using the present methods has heterogeneity, consequently, there is a risk that EVPOME possess poor cell growth activity and capability of oral mucosa regeneration. The previous study was to investigate the capability of EVPOME fabricated with small-sized cell population in which oral mucosal progenitor/stem-cells enriched subpopulation present and the change after EVPOME grafting subcutaneously in mice histologically. In the present study, we elucidated the mechanism of oral mucosa regeneration, especially the role of angiogenesis. As a results, EVPOME with small-sized cell population has high activity and capability of oral mucosal regeneration and faster elongation of epithelium is led by angiogenesis.
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