• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Histological examination of bone regeneration and cell kinetics induced by mesenchymal stem cells: comparison of bone marrow cells with adipose tissue cells

Research Project

Project/Area Number 26463060
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionNiigata University

Principal Investigator

Kojima Taku  新潟大学, 医歯学総合病院, 講師 (90515777)

Co-Investigator(Kenkyū-buntansha) 芳澤 享子  松本歯科大学, 歯学部, 教授 (60303137)
小林 正治  新潟大学, 医歯学系, 教授 (80195792)
Co-Investigator(Renkei-kenkyūsha) AMIZUKA Norio  北海道大学, 大学院歯学総合研究科, 教授 (30242431)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords骨再生 / 間葉系幹細胞 / バイオマテリアル / 骨髄 / 脂肪
Outline of Final Research Achievements

To aim for efficient bone regeneration, we employed tissue engineering which composed of mesenchymal stem cells and biomaterials. Therefore, we examined bone regeneration with bone marrow cells or adipose tissue cells/porous beta-TCP block composites by means of histological analysis. Bone marrow cells and adipose tissue cells obtained from 4-week-old GFP rat were induced into osteoblast-like cell, and then, seeded on a porous beta-TCP block. 10-week-old nude rats were implanted with the blocks in the calvariae, and then the blocks were extracted and examined histochemically. The differentiated bone marrow cells and adipose tissue cells have high osteogenic potential. Therefore, these results suggest that not only bone marrow cells but also adipose tissue cells have possibilities to be effective cell sources for bone regeneration.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] 熱可塑性吸収性プレートとβ-TCPによる骨再生の評価2015

    • Author(s)
      小島 拓,芳澤享子,齊藤 力,小林正治
    • Journal Title

      日口外誌

      Volume: 61 Pages: 642-649

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A histological study of deformation of the mandibular condyle caused by distraction in a rat model.2014

    • Author(s)
      1.Sakagami N, Kobayashi T, Nozawa-Inoue K, Oda K, Kojima T, Maeda T, Saito C
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod.,

      Volume: 118 Pages: 284-294

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] バイオマテリアルと間葉系幹細胞による顎骨再生を目指した三次元的骨再生法の開発-その骨質と機能の評価-2014

    • Author(s)
      小島 拓、芳澤享子、小野由起子、坂上直子、齋藤直朗、長谷川智香、網塚憲生、前田健康、小林正治
    • Organizer
      第30回歯科医学を中心とした総合的な研究を推進する集い
    • Place of Presentation
      歯科医師会館(東京都千代田区)
    • Year and Date
      2014-08-30
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi