| Project/Area Number |
26463062
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
Niwa Hitoshi 大阪大学, 歯学研究科, 教授 (30218250)
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| Co-Investigator(Kenkyū-buntansha) |
前川 博治 大阪大学, 歯学部附属病院, 医員 (10711012)
杉村 光隆 大阪大学, 歯学研究科, 准教授 (90244954)
浜田 尚香 大阪大学, 歯学部附属病院, 医員 (70762558)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Parkinson's disease / orofacial pain / formalin test / pain related behavior / パーキンソン病 / 痛覚 / ラット / 疼痛関連行動 / c-fos / C-Fos / 口腔 / 三叉神経 / ｃ－Fos |
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| Outline of Final Research Achievements |
The effect of Parkinson's disease (PD) on pain sensation in the oral facial area was examined using PD model rats, which were produced by the unilateral injection of 6-OHDA into the medial forebrain bundle. PD model rats were injected with 0.05 mL of 4% formalin into the upper lip. The expression of c-Fos in trigeminal spinal nucleus caudalis (Vc), hypothalamic paraventricular nucleus (PVN), parabrachial nucleus (PBN), periaqueductal gray (PAG), nucleus locus ceruleus (LC), and nucleus raphe magnus (NRM) were explored.
As a result, the number of c-Fos positive cells was significantly smaller in the large cell group in PVN than in the control group. The PVN is an important source of brain oxytocin. The depletion of dopamine may cause the change of the activity of the PVN, which may have influenced the analgesic effects mediated by oxytocin.
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