• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Neural mechanism underlyig hyperalgesia response to orofacial pain in Parkinson's disese model rats

Research Project

Project/Area Number 26463062
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

Niwa Hitoshi  大阪大学, 歯学研究科, 教授 (30218250)

Co-Investigator(Kenkyū-buntansha) 前川 博治  大阪大学, 歯学部附属病院, 医員 (10711012)
杉村 光隆  大阪大学, 歯学研究科, 准教授 (90244954)
浜田 尚香  大阪大学, 歯学部附属病院, 医員 (70762558)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsParkinson's disease / orofacial pain / formalin test / pain related behavior / パーキンソン病 / 痛覚 / ラット / 疼痛関連行動 / c-fos / C-Fos / 口腔 / 三叉神経 / c-Fos
Outline of Final Research Achievements

The effect of Parkinson's disease (PD) on pain sensation in the oral facial area was examined using PD model rats, which were produced by the unilateral injection of 6-OHDA into the medial forebrain bundle. PD model rats were injected with 0.05 mL of 4% formalin into the upper lip. The expression of c-Fos in trigeminal spinal nucleus caudalis (Vc), hypothalamic paraventricular nucleus (PVN), parabrachial nucleus (PBN), periaqueductal gray (PAG), nucleus locus ceruleus (LC), and nucleus raphe magnus (NRM) were explored.
As a result, the number of c-Fos positive cells was significantly smaller in the large cell group in PVN than in the control group. The PVN is an important source of brain oxytocin. The depletion of dopamine may cause the change of the activity of the PVN, which may have influenced the analgesic effects mediated by oxytocin.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2017 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Neural mechanism underlying hyperalgesic response to orofacial painin Parkinson’s disease model rats2015

    • Author(s)
      Hiroharu Maegawa, Yoshinari Morimoto, Chiho Kudo, Hiroshi Hanamoto ,Aiji Boku, Mitsutaka Sugimura, Takafumi Kato, Atsushi Yoshida, Hitoshi Niwa
    • Journal Title

      Neuroscience Research

      Volume: 96 Pages: 59-68

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] パーキンソン病モデルラットにおける痛覚過敏のメカニズムの検討2017

    • Author(s)
      足立奈由香、前川博治、河野彰代、成清 綾、林 正祐、岸本沙樹、丹羽 均
    • Organizer
      第45回日本歯科麻酔学会
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi