| Project/Area Number |
26463065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Shimane University |
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Principal Investigator |
Sekine Joji 島根大学, 医学部, 教授 (20236095)
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| Co-Investigator(Kenkyū-buntansha) |
秀島 克巳 島根大学, 医学部, 助教 (80593673)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 頬脂肪体 / プロテオーム解析 / マイクロアレイ / 組織学的評価 |
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| Outline of Final Research Achievements |
Pedicled buccal fat pad (BFP) fills an anatomical gap consisted of the buccinator muscle, the masseter muscle, and the ramus of the mandible. This study sought to evaluate the applicability of pedicled BFP grafting with a higher number of cases than our previous report in 2015.We evaluated them based on the following criteria: the epithelialisation, the graft infection, the fistula recurrence, the facial contour deficiency, the limitation of the mouth opening, and the facial nerve palsy. Besides, by means of gene expression microarray analysis, we have investigated genes which are potential targets for epithelialisation of BFP.Complete epithelialisation of the BFP occurred within 4 weeks in most of the grafting's. Four weeks postsurgery, no complications occurred in most of the grafting's. BFP grafting appears to be feasible for the reconstruction of surgical defects in the oral region.
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