Study on the restoration factor of the self-conclusion type organization reproduction material by proteomic analysis

• Project/Area Number: 26463065
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Shimane University
• Principal Investigator: Sekine Joji 島根大学, 医学部, 教授 (20236095)
• Co-Investigator(Kenkyū-buntansha): 秀島 克巳 島根大学, 医学部, 助教 (80593673)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 頬脂肪体 / プロテオーム解析 / マイクロアレイ / 組織学的評価

Outline of Final Research Achievements

Pedicled buccal fat pad (BFP) fills an anatomical gap consisted of the buccinator muscle, the masseter muscle, and the ramus of the mandible. This study sought to evaluate the applicability of pedicled BFP grafting with a higher number of cases than our previous report in 2015.We evaluated them based on the following criteria: the epithelialisation, the graft infection, the fistula recurrence, the facial contour deficiency, the limitation of the mouth opening, and the facial nerve palsy. Besides, by means of gene expression microarray analysis, we have investigated genes which are potential targets for epithelialisation of BFP.Complete epithelialisation of the BFP occurred within 4 weeks in most of the grafting's. Four weeks postsurgery, no complications occurred in most of the grafting's. BFP grafting appears to be feasible for the reconstruction of surgical defects in the oral region.

Research Products

• [Journal Article] A New Conception of Oral Potentially Malignant Disorders (PMDs) from Cytological and Clinical Viewpoints and Related Disorders of Upper Digestive Tract (2017)
  • Author(s): Joji Sekine
  • Journal Title: Shimane Journal of Medical Science Volume: -
  • NAID: 120006221244
  • Peer Reviewed
• [Journal Article] Applicability of buccal fat pad grafting for oral reconstruction (2016)
  • Author(s): Aya Yoshino, Yoshiki Nariai, Masaaki Karino, Hiroto Tatsumi, Koji Tsunematsu, Yutaro Takamura, Takahiro Kanno, Chie Yanai, Seiji Kondo, Joji Sekine
  • Journal Title: 40th World Congress of the International College of Surgeons, 62nd Annual Congress of the International College of Surgeons Japan Section, Proceedings Volume: - Pages: 354-354
  • NAID: 130005119901
• [Journal Article] 頬脂肪体を用いた顎口腔再建術の有用性に関する検討 (2015)
  • Author(s): 吉野 綾、成相義樹、狩野正明、辰巳博人、恒松晃司、高村雄太郎、管野貴浩、柳井智恵、近藤誠二、関根浄治
  • Journal Title: 頭頸部癌 Volume: 41（4） Pages: 406-410
  • NAID: 130005119901
  • Peer Reviewed
• [Presentation] Applicability of buccal fat pad for oral reconstruction. (2017)
  • Author(s): Aya Yoshino, Yoshiki Nariai, Takahiro Kanno, Chie Yanai, Joji Sekine.
  • Organizer: 23rd International Conference on Oral and Maxillofacial Surgery, Hong Kong Convention & Exhibition Centre, Hong Kong.
  • Int'l Joint Research
• [Presentation] Applicability of buccal fat pad grafting for oral reconstruction. (2017)
  • Author(s): Aya Yoshino, Yoshiki Nariai, Masaaki Karino, Takahiro Kanno, Joji Sekine.
  • Organizer: The 63rd Annual Congress of International College of Surgeons Japan Section.
  • Int'l Joint Research
• [Presentation] Applicability of buccal fat pad for oral reconstruction (2017)
  • Author(s): Aya Yoshino, Yoshiki Nariai, Takahiro Kanno, Chie Yanai, Joji Sekine
  • Organizer: 23rd International Conference on Oral and Maxillofacial Surgery
  • Place of Presentation: Hong Kong Convention & Exhibition Centre
  • Int'l Joint Research
• [Presentation] Functional oral rehabilitation by osseointegrated implants in reconstructed jaws following oral tumor surgery (2016)
  • Author(s): Joji Sekine
  • Organizer: 40th World Congress of the International College of Surgeons, 62nd Annual Congress of the International College of Surgeons Japan Section
  • Place of Presentation: Kyoto International Conference Center
  • Int'l Joint Research
• [Presentation] Applicability of buccal fat pad grafting for oral reconstruction (2016)
  • Author(s): Aya Yoshino, Yoshiki Nariai, Masaaki Karino, Hiroto Tatsumi, Koji Tsunematsu, Yutaro Takamura, Takahiro Kanno, Chie Yanai, Seiji Kondo, Joji Sekine
  • Organizer: 40th World Congress of the International College of Surgeons, 62nd Annual Congress of the International College of Surgeons Japan Section
  • Place of Presentation: Kyoto International Conference Center
  • Int'l Joint Research
• [Presentation] 顎関節突起基底部骨間隙形成と頬脂肪体有茎弁による顎関節授動術後にインプラントを用いて顎咬合機能回復を行った1例 (2016)
  • Author(s): 関根浄治、恒松晃司、成相義樹
  • Organizer: 公益社団法人日本口腔インプラント学会第36回中国・四国支部学術大会
  • Place of Presentation: 香川県社会福祉総合センター
• [Presentation] 口腔腫瘍切除後の歯科インプラントや埋伏歯の萌出誘導による口腔機能回復 (2016)
  • Author(s): 関根浄治、管野貴浩、狩野正明
  • Organizer: 第34回日本頭蓋顎顔面外科学会学術集会
  • Place of Presentation: 御茶ノ水ソラシティカンファレンスセンター
• [Presentation] Applicability of buccal fat pad grafting for oral reconstruction (2015)
  • Author(s): Aya Yoshino, Yoshiki Nariai, Masaaki Karino, Hiroto Tatsumi, Koji Tsunematsu, Yuta Yoshiki Nariai, Masaaki Karino, Hiroto Tatsumi, Koji Tsunematsu, Yutaro Takamura, Takahiro Kanno, Chie Yanai, Seiji Kondo, Joji Sekine
  • Organizer: 第３９回日本頭頸部癌学会・第４回アジア頭頸部癌学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] Applicability of buccal fat pad grafting for oral reconstruction (2014)
  • Author(s): Aya Yoshino, Yoshiki Nariai, Masaaki Karino, Hiroto Tatsumi, Koji Tsunematsu, Yutaro Takamura Takahiro Kanno, Chie Yanai, Seiji Kondo, Joji Sekine
  • Organizer: The 39th Bienial World Congress of the International College of Surgeons
  • Place of Presentation: Bali International Convention Centre, The Westin Hotel, Nusa Dua, Bari, Indonesia
  • Year and Date: 2014-10-22
• [Presentation] 外傷性顎関節脱臼に起因する顎関節硬直症に対し中間挿入物として頬脂肪体を用いた１例 (2014)
  • Author(s): 辰巳博人, 成相義樹、大熊里依、管野貴浩、関根浄治
  • Organizer: 第16回日本口腔顎顔面外傷学会総会・学術大会
  • Place of Presentation: 米子コンベンションセンター
  • Year and Date: 2014-07-19
• [Presentation] Applicability of buccal fat pad grafting for oral reconstruction (2014)
  • Author(s): Aya Yoshino, Yoshiki Nariai, Masaaki Karino, Yoko Toshihiro, Hiroto Tatsumi, Kohji Tsunematsu, Yutaro Takamura, Takahiro Kanno, Chie Yanai, Seiji Kondo, Joji Sekine
  • Organizer: The International College of Surgeon The 60th Annual Congress of the Japan Section
  • Place of Presentation: ホテルメトロポリタン高崎
  • Year and Date: 2014-06-14