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Study on the restoration factor of the self-conclusion type organization reproduction material by proteomic analysis

Research Project

Project/Area Number 26463065
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionShimane University

Principal Investigator

Sekine Joji  島根大学, 医学部, 教授 (20236095)

Co-Investigator(Kenkyū-buntansha) 秀島 克巳  島根大学, 医学部, 助教 (80593673)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords頬脂肪体 / プロテオーム解析 / マイクロアレイ / 組織学的評価
Outline of Final Research Achievements

Pedicled buccal fat pad (BFP) fills an anatomical gap consisted of the buccinator muscle, the masseter muscle, and the ramus of the mandible. This study sought to evaluate the applicability of pedicled BFP grafting with a higher number of cases than our previous report in 2015.We evaluated them based on the following criteria: the epithelialisation, the graft infection, the fistula recurrence, the facial contour deficiency, the limitation of the mouth opening, and the facial nerve palsy. Besides, by means of gene expression microarray analysis, we have investigated genes which are potential targets for epithelialisation of BFP.Complete epithelialisation of the BFP occurred within 4 weeks in most of the grafting's. Four weeks postsurgery, no complications occurred in most of the grafting's. BFP grafting appears to be feasible for the reconstruction of surgical defects in the oral region.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (11 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] A New Conception of Oral Potentially Malignant Disorders (PMDs) from Cytological and Clinical Viewpoints and Related Disorders of Upper Digestive Tract2017

    • Author(s)
      Joji Sekine
    • Journal Title

      Shimane Journal of Medical Science

      Volume: -

    • NAID

      120006221244

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Applicability of buccal fat pad grafting for oral reconstruction2016

    • Author(s)
      Aya Yoshino, Yoshiki Nariai, Masaaki Karino, Hiroto Tatsumi, Koji Tsunematsu, Yutaro Takamura, Takahiro Kanno, Chie Yanai, Seiji Kondo, Joji Sekine
    • Journal Title

      40th World Congress of the International College of Surgeons, 62nd Annual Congress of the International College of Surgeons Japan Section, Proceedings

      Volume: - Pages: 354-354

    • NAID

      130005119901

    • Related Report
      2016 Research-status Report
  • [Journal Article] 頬脂肪体を用いた顎口腔再建術の有用性に関する検討2015

    • Author(s)
      吉野 綾、成相義樹、狩野正明、辰巳博人、恒松晃司、高村雄太郎、管野貴浩、柳井智恵、近藤誠二、関根浄治
    • Journal Title

      頭頸部癌

      Volume: 41(4) Pages: 406-410

    • NAID

      130005119901

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Applicability of buccal fat pad for oral reconstruction.2017

    • Author(s)
      Aya Yoshino, Yoshiki Nariai, Takahiro Kanno, Chie Yanai, Joji Sekine.
    • Organizer
      23rd International Conference on Oral and Maxillofacial Surgery, Hong Kong Convention & Exhibition Centre, Hong Kong.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Applicability of buccal fat pad grafting for oral reconstruction.2017

    • Author(s)
      Aya Yoshino, Yoshiki Nariai, Masaaki Karino, Takahiro Kanno, Joji Sekine.
    • Organizer
      The 63rd Annual Congress of International College of Surgeons Japan Section.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Applicability of buccal fat pad for oral reconstruction2017

    • Author(s)
      Aya Yoshino, Yoshiki Nariai, Takahiro Kanno, Chie Yanai, Joji Sekine
    • Organizer
      23rd International Conference on Oral and Maxillofacial Surgery
    • Place of Presentation
      Hong Kong Convention & Exhibition Centre
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional oral rehabilitation by osseointegrated implants in reconstructed jaws following oral tumor surgery2016

    • Author(s)
      Joji Sekine
    • Organizer
      40th World Congress of the International College of Surgeons, 62nd Annual Congress of the International College of Surgeons Japan Section
    • Place of Presentation
      Kyoto International Conference Center
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Applicability of buccal fat pad grafting for oral reconstruction2016

    • Author(s)
      Aya Yoshino, Yoshiki Nariai, Masaaki Karino, Hiroto Tatsumi, Koji Tsunematsu, Yutaro Takamura, Takahiro Kanno, Chie Yanai, Seiji Kondo, Joji Sekine
    • Organizer
      40th World Congress of the International College of Surgeons, 62nd Annual Congress of the International College of Surgeons Japan Section
    • Place of Presentation
      Kyoto International Conference Center
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 顎関節突起基底部骨間隙形成と頬脂肪体有茎弁による顎関節授動術後にインプラントを用いて顎咬合機能回復を行った1例2016

    • Author(s)
      関根浄治、恒松晃司、成相義樹
    • Organizer
      公益社団法人日本口腔インプラント学会第36回中国・四国支部学術大会
    • Place of Presentation
      香川県社会福祉総合センター
    • Related Report
      2016 Research-status Report
  • [Presentation] 口腔腫瘍切除後の歯科インプラントや埋伏歯の萌出誘導による口腔機能回復2016

    • Author(s)
      関根浄治、管野貴浩、狩野正明
    • Organizer
      第34回日本頭蓋顎顔面外科学会学術集会
    • Place of Presentation
      御茶ノ水ソラシティカンファレンスセンター
    • Related Report
      2016 Research-status Report
  • [Presentation] Applicability of buccal fat pad grafting for oral reconstruction2015

    • Author(s)
      Aya Yoshino, Yoshiki Nariai, Masaaki Karino, Hiroto Tatsumi, Koji Tsunematsu, Yuta Yoshiki Nariai, Masaaki Karino, Hiroto Tatsumi, Koji Tsunematsu, Yutaro Takamura, Takahiro Kanno, Chie Yanai, Seiji Kondo, Joji Sekine
    • Organizer
      第39回日本頭頸部癌学会・第4回アジア頭頸部癌学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Applicability of buccal fat pad grafting for oral reconstruction2014

    • Author(s)
      Aya Yoshino, Yoshiki Nariai, Masaaki Karino, Hiroto Tatsumi, Koji Tsunematsu, Yutaro Takamura Takahiro Kanno, Chie Yanai, Seiji Kondo, Joji Sekine
    • Organizer
      The 39th Bienial World Congress of the International College of Surgeons
    • Place of Presentation
      Bali International Convention Centre, The Westin Hotel, Nusa Dua, Bari, Indonesia
    • Year and Date
      2014-10-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 外傷性顎関節脱臼に起因する顎関節硬直症に対し中間挿入物として頬脂肪体を用いた1例2014

    • Author(s)
      辰巳博人, 成相義樹、大熊里依、管野貴浩、関根浄治
    • Organizer
      第16回日本口腔顎顔面外傷学会総会・学術大会
    • Place of Presentation
      米子コンベンションセンター
    • Year and Date
      2014-07-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Applicability of buccal fat pad grafting for oral reconstruction2014

    • Author(s)
      Aya Yoshino, Yoshiki Nariai, Masaaki Karino, Yoko Toshihiro, Hiroto Tatsumi, Kohji Tsunematsu, Yutaro Takamura, Takahiro Kanno, Chie Yanai, Seiji Kondo, Joji Sekine
    • Organizer
      The International College of Surgeon The 60th Annual Congress of the Japan Section
    • Place of Presentation
      ホテルメトロポリタン高崎
    • Year and Date
      2014-06-14
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-05-15  

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