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a study of early stage of dental formation by a novel organ culture system

Research Project

Project/Area Number 26463067
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionOkayama University

Principal Investigator

MATSUMURA TATSUSHI  岡山大学, 医歯薬学総合研究科, 講師 (70432648)

Co-Investigator(Kenkyū-buntansha) 山近 英樹  岡山大学, 大学病院, 講師 (10294422)
田畑 純  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (20243248)
平田 あずみ  大阪医科大学, 医学部, 講師 (40263587)
森谷 徳文  岡山大学, 医歯薬学総合研究科, 助教 (60467751)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords歯学 / 歯堤 / 再生医学
Outline of Final Research Achievements

The analysis of dental lamina helps to clear the early stage of dental formation. That analysis contributes to not only establishment of the artificial tooth germ (e.g.; cell source, culture period and safety), but also clarification of the etiology of supernumerary tooth, odontoma and odontogenic tumors.
But the behavior of the dental lamina remains largely unclear due to the difficulty to mimic the procedure. Thus it is extensively necessary to establish the experimental model for the early stage of dental formation. To understand the variety of events of dental lamina during early stage of dental formation, further investigation is needed and our organ culture is essential to develop the experimental model.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Anti-osteoporosis effects of 1,4-dihydroxy-2-naphthoic acid in ovariectomized mice with increasing of bone density2016

    • Author(s)
      Kenichiro Kita, Eiki Yamachika, Masakazu Matsubara, Hidetsugu Tsujigiwa, Nobuhisa Ishida, Norifumi Moritani, Tatsushi Matsumura, Masahide Mizutani, Yuki Fujita, Kiyofumi Takabatake, Kenichiro Ejima, Hitoshi Nagatsuka, Yoshinori Yamaguchi, Seiji Iida
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 28(1) Issue: 1 Pages: 66-72

    • DOI

      10.1016/j.ajoms.2015.07.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Treatment of Osteonecrosis of the Jaw.2015

    • Author(s)
      Yamachika E, Matsubara M, Ikeda A, Matsumura T, Moritani N, Iida S.
    • Journal Title

      Journal of Craniofacial Surgery

      Volume: 27(7) Issue: 7 Pages: 575-577

    • DOI

      10.1097/scs.0000000000002127

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] A NOVEL GUIDE DEVICE OF THE OSTEOTOMY LINE FOR INTRAORAL VERTICAL RAMUS OSTEOTOMY.2015

    • Author(s)
      N. Moritani, T. Matsumura, E. Yamachika, Y. Goda, A. Uemura, N. Nakata, S. Tamura, Y. Yoshioka, S. Iida
    • Organizer
      The 22nd International Conference on Oral & Maxillofacial Surgery (ICOMS)
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A safety reference point for IVRO in mandibular Morphology.2014

    • Author(s)
      Y Goda, T Matsumura, Y Yanagi, N Moritani, M Matsubara, N Ishida, Y Matsui, N Kishimoto, S Iida
    • Organizer
      The 10th Asian Congress of Oral and Maxillo Facial Radiology (ACOMFR)
    • Place of Presentation
      Bali-Indonesia
    • Year and Date
      2014-11-20
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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