a study of early stage of dental formation by a novel organ culture system

• Project/Area Number: 26463067
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Okayama University
• Principal Investigator: MATSUMURA TATSUSHI 岡山大学, 医歯薬学総合研究科, 講師 (70432648)
• Co-Investigator(Kenkyū-buntansha): 山近 英樹 岡山大学, 大学病院, 講師 (10294422) ; 田畑 純 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (20243248) ; 平田 あずみ 大阪医科大学, 医学部, 講師 (40263587) ; 森谷 徳文 岡山大学, 医歯薬学総合研究科, 助教 (60467751)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 歯学 / 歯堤 / 再生医学

Outline of Final Research Achievements

The analysis of dental lamina helps to clear the early stage of dental formation. That analysis contributes to not only establishment of the artificial tooth germ (e.g.; cell source, culture period and safety), but also clarification of the etiology of supernumerary tooth, odontoma and odontogenic tumors.
But the behavior of the dental lamina remains largely unclear due to the difficulty to mimic the procedure. Thus it is extensively necessary to establish the experimental model for the early stage of dental formation. To understand the variety of events of dental lamina during early stage of dental formation, further investigation is needed and our organ culture is essential to develop the experimental model.

Research Products

• [Journal Article] Anti-osteoporosis effects of 1,4-dihydroxy-2-naphthoic acid in ovariectomized mice with increasing of bone density (2016)
  • Author(s): Kenichiro Kita, Eiki Yamachika, Masakazu Matsubara, Hidetsugu Tsujigiwa, Nobuhisa Ishida, Norifumi Moritani, Tatsushi Matsumura, Masahide Mizutani, Yuki Fujita, Kiyofumi Takabatake, Kenichiro Ejima, Hitoshi Nagatsuka, Yoshinori Yamaguchi, Seiji Iida
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: 28(1) Issue: 1 Pages: 66-72
  • DOI: 10.1016/j.ajoms.2015.07.001
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Treatment of Osteonecrosis of the Jaw. (2015)
  • Author(s): Yamachika E, Matsubara M, Ikeda A, Matsumura T, Moritani N, Iida S.
  • Journal Title: Journal of Craniofacial Surgery Volume: 27(7) Issue: 7 Pages: 575-577
  • DOI: 10.1097/scs.0000000000002127
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] A NOVEL GUIDE DEVICE OF THE OSTEOTOMY LINE FOR INTRAORAL VERTICAL RAMUS OSTEOTOMY. (2015)
  • Author(s): N. Moritani, T. Matsumura, E. Yamachika, Y. Goda, A. Uemura, N. Nakata, S. Tamura, Y. Yoshioka, S. Iida
  • Organizer: The 22nd International Conference on Oral & Maxillofacial Surgery (ICOMS)
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] A safety reference point for IVRO in mandibular Morphology. (2014)
  • Author(s): Y Goda, T Matsumura, Y Yanagi, N Moritani, M Matsubara, N Ishida, Y Matsui, N Kishimoto, S Iida
  • Organizer: The 10th Asian Congress of Oral and Maxillo Facial Radiology (ACOMFR)
  • Place of Presentation: Bali-Indonesia
  • Year and Date: 2014-11-20