| Project/Area Number |
26463071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KITAHATA Hiroshi 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (60161486)
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| Co-Investigator(Kenkyū-buntansha) |
堤 保夫 徳島大学, 大学院医歯薬学研究部(医学系), 准教授 (90523499)
川人 伸次 徳島大学, 大学院医歯薬学研究部(医学系), 特任教授 (60284296)
高石 和美 徳島大学, 病院, 講師 (20325286)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心筋保護作用 / Sirtuin / カベオリン / プレコンディショニング / イソフルラン / 吸入麻酔薬 / 虚血再灌流障害 / 細胞膜マイクロドメイン / 心筋保護 / 虚血再灌流 / サーチュイン / アポトーシス |
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| Outline of Final Research Achievements |
Using the mouse myocardial ischemia-reperfusion model, our results show that, volatile anesthetic-induced cardiac protection is dependent on an anti-aging gene, sirtuin, and a membrane microdomain, caveolin.
Additionally, our results suggest that caveolin within the heart are critical for sirtuin-induced cardiac protection via volatile anesthetics.
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