The elucidation of the pathogenesis of the orofacial neuropathicpain and its treatment strategy

• Project/Area Number: 26463073
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Yoshida Mitsuhiro 広島大学, 病院(歯), 講師 (40364153)
• Co-Investigator(Renkei-kenkyūsha): Ishikawa Toshizou 山口大学, 医学部・保健学科, 教授 (90034991)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 神経障害性疼痛 / 慢性疼痛 / 神経栄養因子 / グリア細胞 / 神経因性疼痛 / マイクログリア

Outline of Final Research Achievements

In this study we tried to clarify how microglia cells are activated chronologically and how brain-derived neurotrophic factor relate the mechanism of pathogenesis of neuropathicpain in the central nervous system. Microglia cells are activated before developping chronic pain. The activation of microcells are decreases after developping chronic pain. The facilitation of the secretion of brain-derived neurotrophic factor did not affect the reaction latency to heat stimulation, but ameliolated depressive symptom with chronic pain.

Research Products

• [Journal Article] Dura-evoked neck muscle activity involves purinergic and N-methyl-D-aspartate receptor mechanisms (2015)
  • Author(s): Yao Dongyuan, Yoshida Mitsuhiro, Sessle Barry J.
  • Journal Title: Neuroreport Volume: 26 Issue: 18 Pages: 11551160-11551160
  • DOI: 10.1097/wnr.0000000000000489
  • Peer Reviewed
• [Journal Article] Imipramine ameliorates pain-related negative emotion via induction of brain-derived neurotrophic factor (2014)
  • Author(s): S Yasuda, M Yoshida, H Yamagata, Y Iwanaga, H Suenaga, K Ishikawa, M Nakano, S Okuyama, Y Furukawa, S Furukawa, T Ishikawa
  • Journal Title: Cell Mol Neurobiol Volume: 34 Issue: 8 Pages: 1199-1208
  • DOI: 10.1007/s10571-014-0097-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] The analgesic effect of flurbiprofen in combination with acetaminophen: comparison to that with fentanyl (2016)
  • Author(s): Mitsuhiro Yoshida, Yoshitaka Shimizu, Keita Yoshida, Akari Mukai, Mitsuru Doi, Masahiro Irifune
  • Organizer: International Asociation for Dental Research
  • Place of Presentation: Seoul, Republic Of Korea
  • Year and Date: 2016-06-22
  • Int'l Joint Research
• [Presentation] 抗うつ薬 Imipramine のラット慢性疼痛における気分障害改善と神経栄養因子（BDNF）誘導作用 (2014)
  • Author(s): 安田聖子，岩永泰武，藤村博和，吉田充広，福原佳世子，石川敏三
  • Organizer: 第36回日本疼痛学会
  • Place of Presentation: KKRホテル大阪
  • Year and Date: 2014-06-20 – 2014-06-21
• [Presentation] ノイロトロピンの痛覚－情動系機能障害改善効果：脳由来神経栄養因子（BDNF）誘導作用 (2014)
  • Author(s): 石川敏三，安田聖子，石川浩三，藤村博和，井田唯香，岩永泰武，吉田 充広
  • Organizer: 第36回日本疼痛学会
  • Place of Presentation: KKRホテル大阪
  • Year and Date: 2014-06-20 – 2014-06-21