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Development of a new treatment method for peripheral nerve injury using dental pulp stem cells

Research Project

Project/Area Number 26463080
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

Kurita Kenichi  愛知学院大学, 歯学部, 教授 (40133483)

Co-Investigator(Kenkyū-buntansha) 中島 美砂子  国立研究開発法人国立長寿医療研究センター, その他部局等, その他 (20207773)
平田 仁  名古屋大学, 予防早期医療創成センター, 教授 (80173243)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords再生 / 末梢神経再生 / 末梢神経麻痺 / 歯髄幹細胞 / 挫滅モデル / 麻痺モデル
Outline of Final Research Achievements

In the cell transplant group, the opening of the limb was noticed more prominently than the non-cell transplant group due to the temporal change of the hind paw, and the number of inflammatory cells in the range of the central side 1/2 of the sciatic nerve was smaller than that of the control group. Next, in analysis by anti-Myelin basic protein antibody, in the cell transplant group, the region showing antibody positive in the range of the central side was broad compared with the control group. In the wet weight of the tibialis anterior muscle (wet tibialis anterior muscle weight on the affected side / wet tibialis muscle weight on the unaffected side × 100), the cell transplant group showed a significantly higher value than the control group. We believe that the results suggesting the effect of dental pulp cell transplantation were obtained from this experiment, but we believe further analysis is necessary in the future.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016

All Journal Article (1 results) Presentation (1 results)

  • [Journal Article] 歯髄幹細胞を用いたラット末梢神経挫滅モデルにおける再生治療の開発2016

    • Author(s)
      大桑 雄太、中山 英典、林 勇樹、栗田 賢一、中島 美砂子
    • Journal Title

      Peripheral Nerve

      Volume: 27(2) Pages: 326-326

    • Related Report
      2016 Annual Research Report
  • [Presentation] 歯髄幹細胞を用いたラット末梢神経挫滅モデルにおける再生治療の開発2016

    • Author(s)
      大桑 雄太
    • Organizer
      日本末梢神経学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report 2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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