| Project/Area Number |
26463084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
千田 透子 東北大学, 歯学研究科, 大学院非常勤講師 (40647947)
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| Co-Investigator(Renkei-kenkyūsha) |
RYUSHI KATO 東北大学, 大学院歯学研究科, 大学院非常勤講師 (90706699)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 縫合 / CTGF / 牽引力 / メカニカルストレス / 血管形成 / 骨形成 |
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| Outline of Final Research Achievements |
We have analyzed the function of CTGF during biological response of cranial sutures to tensile force. Tensile force induced the expression of Ctgf and Vegf in sutures 3 hours after loading. The tensile force-induced Vegf expression in sutures was inhibited by the administration of CTGF-neutralizing antibody. The administration of CTGF-neutralizing antibody also inhibited sutural bone formation induced by tensile force. Moreover, we have cultured primary suture-derived cells to analyze CTGF function in vitro. Our findings indicate that CTGF is an essential factor to regulate biological response of sutures to tensile force.
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