Development of Bone Regeneration Method Utilizing Hematopoietic-Mesenchymal Interaction and Clinical Application to Orthodontics
| Project/Area Number |
26463085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OHKUBO Kazumi 東京大学, 医学部附属病院, 講師 (10396715)
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| Co-Investigator(Kenkyū-buntansha) |
岡安 麻里 東京大学, 医学部附属病院, 助教 (10610941)
星 和人 東京大学, 医学部附属病院, 准教授 (30344451)
西條 英人 東京大学, 医学部附属病院, 講師 (80372390)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 造血‐間葉相互作用 / 再生骨 / SCF含有FGF2/PLGA徐放製剤 / 間葉系幹細胞 / 造血幹細胞 / 骨再生 / 造血-間葉相互作用 / 歯科矯正 / FGF徐放化製剤 / SCF徐放化 / SCF含有FGF2徐放化製剤 / 骨髄微小環境形成 / 幹細胞動員 / 添加的骨形成 / FGF-2徐放化 |
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| Outline of Final Research Achievements |
The purpose of this study is to establish a method to promote bone formation and maintenance of bone marrow, utilizing the interaction of hematopoietic and mesenchymal stem cells in order to realize highly efficient and reliable bone regeneration. Eventually, we aim for application to orthodontic treatment. First of all, FGF-2 sustained-release PLGA product that promotes additive bone formation was prepared. Then, based on bone morphological change over time and hematopoietic-mesenchymal signal analysis, the amount of SCF to promote stem cell recruitment to bone marrow was determined. Finally, the SCF-included FGF2 / PLGA product was transplanted into the rat extraction tooth cavity. As a result, regenerative bone was confirmed that bone marrow and stem cell number is maintained for a long term after the transplantation. For application to orthodontic treatment, we are trying the treatment model using rats.
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Report
(4 results)
Research Products
(90 results)
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[Journal Article] T2 and apparent diffusion coefficient of MRI reflect maturation of tissue-engineered auricular cartilage subcutaneously transplanted in rats2016
Author(s)
Fujihara Y, NItta N, Misawa M, Hyodo K, Shirasaki Y, Hayashi K, Kosaka R, Homma K, Numano T, Kuribayashi S, Watanabe Y, Sato J, Ohtomo K, Takato T, Hoshi K
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Journal Title
Tissue Eng Part C Methods
Volume: 22(5)
Issue: 5
Pages: 429-438
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] 8.Kanno Y, Nakatsuka T, Saijo H, Fujihara Y, Atsuhiko H, Chung U, Takato T, Hoshi K.2016
Author(s)
Kanno Y, Nakatsuka T, Saijo H, Fujihara Y, Atsuhiko H, Chung U, Takato T, Hoshi K.
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Journal Title
Computed tomographic evaluation of novel custom-made artificial bones, “CT-bone”, applied for maxillofacial reconstruction.
Volume: 5
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] <b>Hyaline cartilage formation and tumorigenesis of implanted tissues derived from human induced pluripotent stem </b><b>cells </b>2015
Author(s)
Saito T, Yano F, Mori D, Kawata M, Hoshi K, Takato T, Masaki H, Otsu M, Eto K, Nakauchi H, Chung UI, Tanaka S
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Journal Title
Biomedical Research
Volume: 36
Issue: 3
Pages: 179-186
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.2015
Author(s)
Nakayachi M, Ito J, Hayashida C, Ohyama Y, Kakino A, Okayasu M, Sato T, Ogasawara T, Kaneda T, Suda N, Sawamura T, Hakeda Y
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Journal Title
Bone. 75:170-182
Volume: 75
Pages: 170-182
DOI
Related Report
Peer Reviewed / Open Access
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[Book] 腎と骨代謝2015
Author(s)
星 和人
Total Pages
70
Publisher
株式会社 日本メディカルセンター
Related Report
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[Book] 再生医療2015
Author(s)
星 和人
Total Pages
65
Publisher
株式会社メディカルレビュー社
Related Report
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[Book] 日本臨床2015
Author(s)
星 和人
Total Pages
578
Publisher
株式会社日本臨牀社
Related Report
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[Book] 顎顔面補綴2015
Author(s)
星 和人
Total Pages
23
Publisher
一般社団法人日本顎顔面補綴学会
Related Report
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[Book] 人工臓器2015
Author(s)
西條 英人
Total Pages
93
Publisher
日本人工臓器学会
Related Report
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[Book] 再生医療2015
Author(s)
西條 英人
Total Pages
65
Publisher
株式会社メディカルレビュー社
Related Report
