| Project/Area Number |
26463085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OHKUBO Kazumi 東京大学, 医学部附属病院, 講師 (10396715)
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| Co-Investigator(Kenkyū-buntansha) |
岡安 麻里 東京大学, 医学部附属病院, 助教 (10610941)
星 和人 東京大学, 医学部附属病院, 准教授 (30344451)
西條 英人 東京大学, 医学部附属病院, 講師 (80372390)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 造血‐間葉相互作用 / 再生骨 / SCF含有FGF2/PLGA徐放製剤 / 間葉系幹細胞 / 造血幹細胞 / 骨再生 / 造血-間葉相互作用 / 歯科矯正 / FGF徐放化製剤 / SCF徐放化 / SCF含有FGF2徐放化製剤 / 骨髄微小環境形成 / 幹細胞動員 / 添加的骨形成 / FGF-2徐放化 |
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| Outline of Final Research Achievements |
The purpose of this study is to establish a method to promote bone formation and maintenance of bone marrow, utilizing the interaction of hematopoietic and mesenchymal stem cells in order to realize highly efficient and reliable bone regeneration. Eventually, we aim for application to orthodontic treatment. First of all, FGF-2 sustained-release PLGA product that promotes additive bone formation was prepared. Then, based on bone morphological change over time and hematopoietic-mesenchymal signal analysis, the amount of SCF to promote stem cell recruitment to bone marrow was determined. Finally, the SCF-included FGF2 / PLGA product was transplanted into the rat extraction tooth cavity. As a result, regenerative bone was confirmed that bone marrow and stem cell number is maintained for a long term after the transplantation. For application to orthodontic treatment, we are trying the treatment model using rats.
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