Development of the treatment of the skeletal muscle atrophy through the IGF-1 signaling in the growth period
| Project/Area Number |
26463095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KAWAI Nobuhiko 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (40437588)
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| Co-Investigator(Kenkyū-buntansha) |
二川 健 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (20263824)
田中 栄二 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (40273693)
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| Research Collaborator |
NOJI Sumihare
KINOUCHI Nao
MORI Hiroyo
HIRASAKA Katsuya
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨格筋萎縮 / ユビキチンン-プロテアソーム経路 / IGF-1シグナル / Cbl-b / 機能性ペプチド / ユビキチン-プロテアソーム経路 |
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| Outline of Final Research Achievements |
In atrophied skeletal muscles, ubiquitin ligase, Cbl-b, increases and it stimulates the ubiquitination and degradation of IRS-1, resulting in IGF-1 resistance. In this study, we evaluate the efficacy of application of anti-ubiquitination peptide that inhibits the interaction between Cbl-b and IRS-1 into masseter muscles of C57BL/6 wild-type mice fed with soft food from 3 week old to 10 week old. Sectional area of masseter muscles treated with the peptide was larger compared to non-treated muscles. These results suggest that application of anti-ubiquitination peptide could be an effective tool for therapeutic use for muscular atrophy by maintenance of proper IGF-1 signaling.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Prevention of skeletal muscle atrophy in vitro using anti-ubiquitination oligopeptide carried by atelocollagen2015
Author(s)
Kawai N, Hirasaka K, Maeda T, Haruna M, Shiota C, Ochi A, Abe T, Kohno S, Ohno A, Teshima-Kondo S Mori H, Tanaka E, Nikawa T
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Journal Title
Biochim Biophys Acta Molecular Cell Research
Volume: 1853
Issue: 5
Pages: 873-880
DOI
Related Report
Peer Reviewed / Open Access
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