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Molecular imaging of masticatory muscle fatigue with skeletal class III patients by mfMRI and 31P-MRS

Research Project

Project/Area Number 26463096
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionKyushu University

Principal Investigator

Kitahara Toru  九州大学, 大学病院, 講師 (00274473)

Co-Investigator(Kenkyū-buntansha) 湯浅 賢治  福岡歯科大学, 口腔歯学部, 教授 (40136510)
飯久保 正弘  東北大学, 歯学研究科, 講師 (80302157)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords咀嚼筋疲労 / 筋機能MRI / 31P-MRS / 下顎前突症 / MRS / 顎変形症
Outline of Final Research Achievements

We have previously demonstrated that muscle function MRI (mfMRI) and 31P-MRS are useful for assessing masseter fatigue. We attempted to establish a measurement method for masseter fatigue using the T2 relaxation time by mfMRI along with creatine phosphate (PCr) and inorganic phosphorus (Pi) by 31P-MRS in patients with mandibular protrusions as well as healthy subjects.
The average T2 time indicated a transient increase in both groups prior to and following experimental clenching. Moreover, the average T2 value of the patient group indicated a significant increase compared to that of the healthy group. PCr indicated a transient decreasing tendency in both groups with a tendency for fewer changes in the patient group compared to those in the healthy group. In addition, both groups indicated a transient Pi increasing tendency.
mfMRI and 31P-MRS are believed useful in assessing masseter fatigue in patients with mandibular protrusions.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016 2015 2014

All Presentation (6 results)

  • [Presentation] 下顎前突症患者における筋機能MRIおよび31P-MRSを用いた咀嚼筋疲労の分子イメージング2018

    • Author(s)
      荒川 雅博, 北原 亨, 飯久保正弘, 湯浅賢治, 髙橋 一郎
    • Organizer
      日本顎変形症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 下顎前突症患者における筋機能MRIおよび31P-MRSを用いた咀嚼筋疲労の分子イメージング2018

    • Author(s)
      荒川 雅博, 北原 亨, 飯久保正弘, 湯浅賢治, 髙橋 一郎
    • Organizer
      九州矯正歯科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 下顎前突症患者における筋機能MRIおよび31P-MRSを用いた咀嚼筋疲労の分子イメージング2017

    • Author(s)
      荒川 雅博, 北原 亨, 飯久保正弘, 湯浅賢治, 髙橋 一郎
    • Organizer
      日本矯正歯科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 筋機能MRIおよび31P-MRSによる咬筋疲労分子イメージング2016

    • Author(s)
      北原亨、飯久保正弘、湯浅賢治、高橋一郎
    • Organizer
      九州矯正歯科学会学術大会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2016-02-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 咀嚼筋疲労の生理・生化学的機能評価の取り組み2015

    • Author(s)
      北原 亨
    • Organizer
      日本矯正歯科学会大会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 筋機能MRIおよび31P-MRSを用いた咀嚼筋疲労の分子イメージング2014

    • Author(s)
      北原亨、飯久保正弘、湯浅賢治、高橋一郎
    • Organizer
      第73回日本矯正歯科学会大会
    • Place of Presentation
      千葉市
    • Year and Date
      2014-10-20 – 2014-10-22
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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