Molecular imaging of masticatory muscle fatigue with skeletal class III patients by mfMRI and 31P-MRS
| Project/Area Number |
26463096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
湯浅 賢治 福岡歯科大学, 口腔歯学部, 教授 (40136510)
飯久保 正弘 東北大学, 歯学研究科, 講師 (80302157)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 咀嚼筋疲労 / 筋機能MRI / 31P-MRS / 下顎前突症 / MRS / 顎変形症 |
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| Outline of Final Research Achievements |
We have previously demonstrated that muscle function MRI (mfMRI) and 31P-MRS are useful for assessing masseter fatigue. We attempted to establish a measurement method for masseter fatigue using the T2 relaxation time by mfMRI along with creatine phosphate (PCr) and inorganic phosphorus (Pi) by 31P-MRS in patients with mandibular protrusions as well as healthy subjects.
The average T2 time indicated a transient increase in both groups prior to and following experimental clenching. Moreover, the average T2 value of the patient group indicated a significant increase compared to that of the healthy group. PCr indicated a transient decreasing tendency in both groups with a tendency for fewer changes in the patient group compared to those in the healthy group. In addition, both groups indicated a transient Pi increasing tendency.
mfMRI and 31P-MRS are believed useful in assessing masseter fatigue in patients with mandibular protrusions.
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Report
(5 results)
Research Products
(6 results)
