| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Functional role of TGF-beta and BMP cross talk during palatogenesis has not been fully understand. The objective was to investigate cross talk between TGF-beta and BMP signaling during palatal development. The palates treated inhibitor of TbrI and TbrII decreased approximately 90% of both receptor expressions compared to the control. As the phenotype treated with inhibitor TbrI/II, approximately 90% palates were remained medial edge epithelium (MEE) cells at E13 + 72 h. The phospho-Smad2/3 and phospho-Smad1/5 were significantly decreased comparing with control. The present study suggested that TGF-beta and BMP could be linked to events during palatogenesis through both receptors function. The inhibitor treatments resulted in persistent MEE cell signaling, which has been shown to be linked to a failure to complete palatal fusion events. This event could be strong associate with TGF-beta and BMP cross talk signaling pathway.
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