| Project/Area Number |
26463101
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
馬谷原 琴枝 日本大学, 歯学部, 講師 (60440046)
|
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| Research Collaborator |
TSURUMACHI Niina
SAKAGUCHI Masahito
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | DFAT / 骨形成促進作用 / 急速拡大 / 上顎正中口蓋縫合 / 脱分化脂肪細胞 / 正中口蓋縫合 / 骨形成促進 / マイクロＣＴ / ＬＬＬＴ / ＤＦＡＴ / 間葉系幹細胞 |
|---|
| Outline of Final Research Achievements |
As a result of setting conditions for isolating a large number of DFATs, it was found to be optimal to prepare DFAT from mature adipocyte fraction of less than 40 μm diameter, and to treat with 0.02% collagenase for adipose tissue separation.
In the transplantation experiment of DFAT injection into the rapid expansion site of rat maxillary mid-palatal suture using micro-CT images, there was a tendency to promote osteogenesis in the sutured area after DFAT injection compared with the control group, but there was no significant difference.
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