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Elucidation of the molecular mechanisms of the periodontal tissue repair

Research Project

Project/Area Number 26463104
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionOkayama University (2015-2016)
Matsumoto Dental University (2014)

Principal Investigator

Nakano Keisuke  岡山大学, 医歯薬学総合研究科, 准教授 (10325095)

Co-Investigator(Kenkyū-buntansha) 村岡 理奈  松本歯科大学, 歯学部, 助教 (20549430)
辻極 秀次  岡山理科大学, 理学部, 教授 (70335628)
川上 敏行  松本歯科大学, 総合歯科医学研究所, 教授 (80104892)
Research Collaborator NAGATSUKA Hitoshi  岡山大学, 医歯(薬)学総合研究科, 教授 (70237535)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords歯根膜 / 骨髄幹細胞 / 歯周組織 / 歯髄組織 / メカニカルストレス / 歯科矯正学 / リモデリング / GFPマウス / 創傷治癒 / 骨髄移植 / GFP / 組織修復
Outline of Final Research Achievements

We demonstrated the following results in this study.
1. Bone marrow stem cells have a potential to differentiate into dental pulp cells and periodontal ligament cells. 2. Bone marrow stem cells engraft in the active remodeling tissues. 3. There were close relations in the expression of HSPs and Neuroendocrine-related factors and bone marrow drived cell in the periodontal ligament under injurious stimuli. 4.These results can be applied to development of new orthodontic treatment and the effective treatment of the injury.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (39 results)

All 2016 2015 2014

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 13 results,  Acknowledgement Compliant: 6 results) Presentation (26 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Pathological Analysis of Cell Differentiation in Cholesterol Granulomas Experimentally Induced in Mice.2016

    • Author(s)
      Sakai K, Nakano K, Matsuda S, Tsujigiwa H, Ochiai T, Shoumura M, Osuga N, Hasegawa H, Kawakami T.
    • Journal Title

      Int J Med Sci

      Volume: 13(3) Issue: 3 Pages: 220-224

    • DOI

      10.7150/ijms.13853

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Migration and Differentiation of GFP-transplanted Bone Marrow-derived Cells into Experimentally Induced Periodontal Polyp in Mice2016

    • Author(s)
      Matsuda S, Shoumura M, Osuga N, Tsujigiwa H, Nakano K, Okafuji N, Ochiai T, Hasegawa H, Kawakami T.
    • Journal Title

      Int J Med Sci

      Volume: 13(7) Issue: 7 Pages: 500-506

    • DOI

      10.7150/ijms.15671

    • NAID

      120006422718

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overview of Cytological Dynamics of Periodontal Ligament Inflammatory Lesions.2016

    • Author(s)
      Matsuda S, Nakano K, Tsujigiwa H, Takabatake K, Okafuji N, Shoumura M, Osuga N, Nagatsuka H and Kawakami T
    • Journal Title

      Int J Dent Oral Sci

      Volume: S9 Pages: 1-7

    • DOI

      10.19070/2377-8075-si09001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Functional Role of HSP47 in the Periodontal Ligament Subjected to Occlusal Overload in Mice.2015

    • Author(s)
      Hiroaki Mimura, Tatsuo Takaya, Saeka Matsuda, Keisuke Nakano, Rina Muraoka, Mihoko Tomida, Norimasa Okafuji, Takeo Fujii, Toshiyuki Kawakami.
    • Journal Title

      Int J Med Sci

      Volume: 13 Issue: 4 Pages: 248-254

    • DOI

      10.7150/ijms.14129

    • NAID

      120006242001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cytological Kinetics of Periodontal Ligament in an Experimental Occlusal Trauma Model2015

    • Author(s)
      Takaya T, Mimura H, Matsuda S, Nakano K, Tsujigiwa H, Tomida M, Okafuji N, Fujii T, and Kawakami T
    • Journal Title

      Int J Med Sci

      Volume: 12 Issue: 7 Pages: 544-551

    • DOI

      10.7150/ijms.12217

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Histological Evaluation of Periodontal Ligament in Response to Orthodontic Mechanical Stress in Mice2015

    • Author(s)
      Kaneko K, Matsuda S, Muraok R, Nakano K, Iwasaki T, Tomida M, Tsujigiwa H, Nagatsuka H, and Kawakami T
    • Journal Title

      Int J Med Sci

      Volume: 12 Issue: 9 Pages: 689-694

    • DOI

      10.7150/ijms.12883

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Notch as a possible cell differentiation factor in pleomorphic adenomas2015

    • Author(s)
      Takamine K, Ueda Y, Nakano K, Ochiai T, Sugita Y, Kubo K, Maeda H, Hasegawa H and Kawakami T.
    • Journal Title

      Int J Med Sci

      Volume: 12 Issue: 10 Pages: 759-763

    • DOI

      10.7150/ijms.12882

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pathological Examination of Experimentally Induced Periodontal Polyp in Mice2015

    • Author(s)
      Matsuda S, Yokoi Y, Moriyama K, Shoumura M, Osuga N, Nakano K and Kawakami T
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 24 Issue: 4 Pages: 397-400

    • DOI

      10.2485/jhtb.24.397

    • NAID

      130005104332

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Vertical ridge augmentation using allograft and synthetic hydroxyapatites after strategic extraction.2014

    • Author(s)
      Naruse, K., Udagawa, N., Garg, A., Nakamura, M., Nakano, K.
    • Journal Title

      Clinical Advances in Periodontic

      Volume: 4 Issue: 2 Pages: 81-87

    • DOI

      10.1902/cap.2012.120055

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validity of W Angle and YEN Angle in a Sample from Pakistani and Bangladeshi Populations2014

    • Author(s)
      Alam MK, Qamruddin I, Muraoka R, Nakano K, Okafuji N
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 23 Issue: 3 Pages: 351-356

    • DOI

      10.2485/jhtb.23.351

    • NAID

      130004848428

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Experimental Model of Occlusal Trauma in Mouse Periodontal Tissues2014

    • Author(s)
      Fujii T, Takaya T, Mimura H, Osuga N, Matsuda S, Nakano K.
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 23 Issue: 3 Pages: 377-380

    • DOI

      10.2485/jhtb.23.377

    • NAID

      130004848432

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Validity and Reliability of Digital Model Measurements: A Digital Stereomicroscopic Study2014

    • Author(s)
      Shahid F, Alam MK, Khamis MF, Muraoka R, Nakano K, Okafuji N
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 23 Issue: 4 Pages: 439-444

    • DOI

      10.2485/jhtb.23.439

    • NAID

      130004700429

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 外傷性ストレスに対する歯周組織に関する実験的歯間分離モデルによる検討2014

    • Author(s)
      岡藤範正,中野敬介,鍋山篤史,山木貴子,魚住智子,安東信行,横井由紀子,大須賀直人,西川康博
    • Journal Title

      日外傷歯誌

      Volume: 10 Pages: 27-33

    • NAID

      40020386044

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 歯科矯正学的メカニカルストレスが引き起こすマウス歯根膜におけるHSP70の免疫組織化学的発現推移.2016

    • Author(s)
      村岡理奈,中野敬介,川上敏行,山田一尋
    • Organizer
      日本矯正歯科学会大会(第75回)
    • Place of Presentation
      徳島
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Cell migration and differentiation of BMDCs into periodontal polyp2016

    • Author(s)
      Matsuda S, Shoumura M, Osuga N, Tsujigiwa H, Nakano K, Okafuji N, Ochiai T, Hasegawa H and Kawakami T
    • Organizer
      European Association of Oral Medicine (13th)
    • Place of Presentation
      Torino
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HSP70 in recovery of the mouse PDL by mechanical stress.2016

    • Author(s)
      Muraoka R, Nakano K, Yamada K and Kawakami T.
    • Organizer
      European Association of Oral Medicine (13th)
    • Place of Presentation
      Torino
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] コレステリン肉芽腫における骨髄由来の血管内皮細胞の増殖.2016

    • Author(s)
      松田紗衣佳,中野敬介,正村正仁,大須賀直人,落合隆永,辻極秀次,長塚 仁,長谷川博雅,川上敏行
    • Organizer
      硬組織再生生物学会総会(25回)
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] 歯科矯正学的メカニカルストレスによる歯周組織の改造.2016

    • Author(s)
      金子 圭子,松田 紗衣佳,村岡 理奈,中野 敬介,富田 美穂子,辻極 秀次,長塚 仁,川上敏行
    • Organizer
      日本口腔科学会中部地方部会(59回)
    • Place of Presentation
      塩尻
    • Related Report
      2016 Annual Research Report
  • [Presentation] メカニカルストレスが惹起するマウス歯根膜の傷害と回復におけるHSP70の発現推移.2016

    • Author(s)
      村岡理奈,中野敬介,山田一尋,川上敏行
    • Organizer
      日本口腔科学会中部地方部会(59回)
    • Place of Presentation
      塩尻
    • Related Report
      2016 Annual Research Report
  • [Presentation] 実験的咬合性外傷部の歯根膜組織における HSP47 の発現推移.2016

    • Author(s)
      三村泰亮,高谷達夫,中野敬介,松田紗依佳,富田美穂子,岡藤範正,藤井健男,川上敏行
    • Organizer
      日本口腔科学会中部地方部会(59回)
    • Place of Presentation
      塩尻
    • Related Report
      2016 Annual Research Report
  • [Presentation] 実験的咬合性外傷の歯根膜部における創傷と治癒.2016

    • Author(s)
      髙谷達夫,三村泰亮,松田 紗依佳,中野敬介,辻極秀次,富田 美穂子,岡藤範正,藤井健男,川上敏行.
    • Organizer
      日本口腔科学会中部地方部会(59回)
    • Place of Presentation
      塩尻
    • Related Report
      2016 Annual Research Report
  • [Presentation] 歯髄における傷害反応とその回復におけるHSPの発現.2016

    • Author(s)
      斉藤進之介,鍋山篤史,中野敬介,岡藤範正,川上敏行
    • Organizer
      日本口腔科学会中部地方部会(59回)
    • Place of Presentation
      塩尻
    • Related Report
      2016 Annual Research Report
  • [Presentation] 骨髄間葉細胞由来の血管内皮細胞の実験的コレステリン肉芽腫における増殖.2016

    • Author(s)
      松田紗衣佳,中野敬介,正村正仁,大須賀直人,落合隆永,辻極秀次,長塚 仁,長谷川博雅,川上敏行
    • Organizer
      日本口腔科学会中部地方部会(59回)
    • Place of Presentation
      塩尻
    • Related Report
      2016 Annual Research Report
  • [Presentation] 歯科矯正力が惹起するマウス歯根膜細胞におけるHSP47の免疫組織化学的発現推移2015

    • Author(s)
      村岡理奈,倉田和之,松田浩和,中野敬介,川上敏行,山田一尋
    • Organizer
      日本矯正歯科学会大会(第74回)
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] HSP27 expression as a possible molecular chaperone in the periodontal ligament cells due to orthodontic mechanical stress2015

    • Author(s)
      Muraoka R, Kurata K, Nakano K, Yamada K, Kawakami T
    • Organizer
      The 46th International Congress of the Italian Society of Orthodontics
    • Place of Presentation
      Fieramilano(Milano, Itary)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 実験的咬合性外傷における歯根膜中のHSP47の発現推移2015

    • Author(s)
      三村泰亮,高谷達夫,中野敬介,松田紗衣佳,富田美穂子,岡藤範正,藤井健男,川上敏行.
    • Organizer
      硬組織再生生物学会(第23回)
    • Place of Presentation
      日大阪歯科大学(大阪)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
  • [Presentation] メカニカルストレスが惹起するマウス歯根膜におけるHSP70の免疫組織化学的発現推移2015

    • Author(s)
      村岡理奈,松田浩和,山田一尋,中野敬介,川上敏行
    • Organizer
      硬組織再生生物学会(第23回)
    • Place of Presentation
      日大阪歯科大学(大阪)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 実験的咬合性外傷における歯周組織変化2015

    • Author(s)
      髙谷達夫,三村泰亮,松田紗依佳,中野敬介,辻極秀次,富田美穂子,岡藤範正,藤井健男,川上敏行
    • Organizer
      硬組織再生生物学会(第23回)
    • Place of Presentation
      日大阪歯科大学(大阪)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 実験的コレステリン肉芽腫における骨髄間葉細胞由来の血管内皮細胞2015

    • Author(s)
      松田紗衣佳,中野敬介,正村正仁,大須賀直人,落合隆永,辻極秀次,長塚 仁,長谷川博雅,川上敏行
    • Organizer
      硬組織再生生物学会(第23回)
    • Place of Presentation
      日大阪歯科大学(大阪)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report
  • [Presentation] マウスにおける実験的コレステリン肉芽腫の細胞動態に関する検討2015

    • Author(s)
      松田紗衣佳,中野敬介,落合隆永,辻極秀次,長塚 仁,長谷川博雅,川上敏行
    • Organizer
      日本臨床口腔病理学会総会(第26回)
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 歯科矯正学的メカニカルストレスによるマウス歯周組織改造における細胞動態2015

    • Author(s)
      金子圭子,松田紗衣佳,辻極秀次,中野敬介,長塚 仁,川上敏行
    • Organizer
      日本臨床口腔病理学会総会(第26回)
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2015-07-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 実験的に惹起させた歯根膜息肉の病理組織学的検討2014

    • Author(s)
      松田紗衣佳,中野敬介,正村正仁,大須賀直人,辻極秀次,川上敏行
    • Organizer
      歯科基礎医学会総会(第56回)
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] マウスに惹起した咬合性外傷の病理組織学的検討2014

    • Author(s)
      三村泰亮,髙谷達夫,中野敬介,松田紗衣佳,岡藤範正,大須賀直人,川上敏行,藤井健男
    • Organizer
      歯科基礎医学会総会(第56回)
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯根膜における実験的咬合性外傷の細胞動態2014

    • Author(s)
      高谷達夫,三村泰亮,松田紗依佳,中野敬介,川上敏行,岡藤範正,大須賀直人
    • Organizer
      歯科基礎医学会総会(第56回)
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 糊剤根管充填材に対するマウス皮下組織の反応2014

    • Author(s)
      正村正仁,松田紗衣佳,大須賀直人,中野敬介,川上敏行
    • Organizer
      歯科基礎医学会総会(第56回)
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 移植骨髄由来細胞の歯周組織への移動と細胞分化2014

    • Author(s)
      辻極秀次,村岡理奈,中野敬介,富田美穂子,高畠清文,玉村 亮,長塚 仁,川上敏行
    • Organizer
      硬組織再生生物学会(第23回)
    • Place of Presentation
      中山医科大学(台湾 台中市)
    • Year and Date
      2014-08-22
    • Related Report
      2014 Research-status Report
  • [Presentation] マウスに惹起させた歯根膜息肉の病理学的検討2014

    • Author(s)
      松田紗衣佳,中野敬介,正村正仁,大須賀直人,辻極秀次,川上敏行
    • Organizer
      硬組織再生生物学会(第23回)
    • Place of Presentation
      中山医科大学(台湾 台中市)
    • Year and Date
      2014-08-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯科矯正学的メカニカルストレスによる歯周組織の改造現象2014

    • Author(s)
      村岡理奈,金子圭子,中野敬介,山田一尋,川上敏行
    • Organizer
      硬組織再生生物学会(第23回)
    • Place of Presentation
      中山医科大学(台湾 台中市)
    • Year and Date
      2014-08-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 外傷ストレスを負荷した歯周組織変化 ―実験的歯間分離による検討―2014

    • Author(s)
      岡藤 範正,中野敬介,魚住 智子,山木貴子,安東 信行,鍋山 篤史,横井由紀子,大須賀直人,西川康弘
    • Organizer
      日本外傷歯学会総会・学術大会 (第14回)
    • Place of Presentation
      大阪歯科大学(大阪市)
    • Year and Date
      2014-07-27
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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