| Project/Area Number |
26463104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Okayama University (2015-2016)
Matsumoto Dental University (2014) |
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Principal Investigator |
Nakano Keisuke 岡山大学, 医歯薬学総合研究科, 准教授 (10325095)
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| Co-Investigator(Kenkyū-buntansha) |
村岡 理奈 松本歯科大学, 歯学部, 助教 (20549430)
辻極 秀次 岡山理科大学, 理学部, 教授 (70335628)
川上 敏行 松本歯科大学, 総合歯科医学研究所, 教授 (80104892)
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| Research Collaborator |
NAGATSUKA Hitoshi 岡山大学, 医歯(薬)学総合研究科, 教授 (70237535)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯根膜 / 骨髄幹細胞 / 歯周組織 / 歯髄組織 / メカニカルストレス / 歯科矯正学 / リモデリング / GFPマウス / 創傷治癒 / 骨髄移植 / GFP / 組織修復 |
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| Outline of Final Research Achievements |
We demonstrated the following results in this study.
1. Bone marrow stem cells have a potential to differentiate into dental pulp cells and periodontal ligament cells. 2. Bone marrow stem cells engraft in the active remodeling tissues. 3. There were close relations in the expression of HSPs and Neuroendocrine-related factors and bone marrow drived cell in the periodontal ligament under injurious stimuli. 4．These results can be applied to development of new orthodontic treatment and the effective treatment of the injury.
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