Effect of taste stimulation into pharynx on swallowing in the developmental process

• Project/Area Number: 26463108
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Niigata University
• Principal Investigator: Nakamura Yuki 新潟大学, 医歯学系, 助教 (70452779)
• Co-Investigator(Kenkyū-buntansha): 井上 誠 新潟大学, 医歯学系, 教授 (00303131) ; 早崎 治明 新潟大学, 医歯学系, 教授 (60238095)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 嚥下 / 咽頭 / 化学刺激 / 摂食 / 摂食嚥下 / 味覚 / 発達

Outline of Final Research Achievements

Chemical stimulation of the pharynx is effective in eliciting swallowing. We investigated the effect of taste solutions on the elicitation of swallowing in human. The results indicated that stimulation of the pharyngeal region with sour solutions facilitates swallowing, suggesting that the facilitation may be due to increases of sensory inputs. Moreover, we tested in anesthetized or unanethetized rats whether there were particular neuron activities in cortical area and brain stem during feeding by using multi-channel neural recordings and stimulation applications.

Research Products

• [Int'l Joint Research] The University of Chicago(米国)
• [Journal Article] Sagittal plane kinematics of the jaw and hyolingual apparatus during swallowing in Macaca mulatta. (2017)
  • Author(s): Nakamura Y, Iriarte-Diaz J, Arce-McShane F, Orsbon C, Brown KA, Eastment M, Sessle BJ, Inoue M, Ross CF, Takahashi K
  • Journal Title: Dysphagia Volume: －
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Central odontogenic fibroma associated with eruption disturbance of a permanent incisor in a six-year-old girl (2016)
  • Author(s): Nakamura Y, Masuda K, Yamaza H, Nonaka K
  • Journal Title: Int J Dentistry Oral Sci Volume: 03(3) Pages: 205-208
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differential response properties of peripherally and cortically evoked swallows by electrical stimulation in anesthetized rats. (2016)
  • Author(s): Tsujimura T, Tsuji K, Magara J, Sakai S, Suzuki T, Nakamura Y, Nozawa-Inoue K, Inoue M
  • Journal Title: Brain Red Bull Volume: 122 Pages: 12-18
  • DOI: 10.1016/j.brainresbull.2016.02.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Changes in jaw muscle activity and physical property of foods with different textures during chewing. (2015)
  • Author(s): Iguchi H, Magara J, Nakamura Y, Tsujimura T, Ito K, Inoue M
  • Journal Title: Physiol Behav Volume: 152 Pages: 217-224
  • DOI: 10.1016/j.physbeh.2015.10.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Peripheral and central control of swallowing initiation in healthy humans. (2015)
  • Author(s): Aida S, Takeishi R, Magara J, Watanabe M, Ito K, Nakamura Y, Tsujimura T, Hayashi H, Inoue M
  • Journal Title: Physiol Behav Volume: 151 Pages: 404-411
  • DOI: 10.1016/j.physbeh.2015.08.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Changes in the frequency of swallowing during electrical stimulation of superior laryngeal nerve in rats (2015)
  • Author(s): Tsuji K，Tsujimura T, Magara J, Sakai S, Nakamura Y, Inoue M
  • Journal Title: Brain Res Bull Volume: 111 Pages: 53-61
  • DOI: 10.1016/j.brainresbull.2014.12.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Spectral interactions between the primary motor cortex and the primary somatosensory cortex around the swallow onset during natural feeding of macaque monkey. (2016)
  • Author(s): Takahashi K, Nakamura Y, Arce-Mcshane FI, Sessle B, Inoue M
  • Organizer: Dysphagia Research Society 24th Annual Meeting
  • Place of Presentation: Tucson, USA
  • Year and Date: 2016-02-25
• [Presentation] Visualizing large datasets of primate hyolingual feeding behavior in low dimensions. (2016)
  • Author(s): Orsbon CP, Nakamura Y, Palmer SE, Ross CF
  • Organizer: Society for integrative and Comparative Biology Annual Meeting 2016
  • Place of Presentation: Portland, USA
  • Year and Date: 2016-01-03
• [Presentation] Spectral profiles of local field potentials of somatosensory and motor cortices during feeding. Society for Neuroscience Satellite symposium (2015)
  • Author(s): Nakamura Y, Takahashi K, Brown KA, Arce-McShane FI, Hatsopoulos NG, Ross CF
  • Organizer: Society for Neuroscience Satellite symposium
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-11-16
• [Presentation] Semiautomatic marker tracking of tongue positions captured by videofluoroscopy during primate feeding. (2015)
  • Author(s): Best MD, Nakamura Y, Kijak NA, Allen MJ, Lever TE, Hatsopoulos NG, Ross CF, Takahashi K
  • Organizer: 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Milano, Italy
  • Year and Date: 2015-08-25
• [Presentation] Features of swallowing related parameters in a kinematic study of feeding in the macaque. (2015)
  • Author(s): Nakamura Y, Takahashi K, Arce-McShane F, Inoue M, Ross C
  • Organizer: The Dysphagia Research Society 23rd Annual Meeting
  • Place of Presentation: Chicago, The Westin Michigan Avenue Chicago
  • Year and Date: 2015-03-12 – 2015-03-14
• [Presentation] Phase dynamics of beta oscillations in orofacial part of the primary motor cortex around swallowing during natural feeding behavior. (2015)
  • Author(s): Takahashi K, Nakamura Y, Hatsopoulos N, Ross C
  • Organizer: The Dysphagia Research Society 23rd Annual Meeting
  • Place of Presentation: Chicago, The Westin Michigan Avenue Chicago
  • Year and Date: 2015-03-12 – 2015-03-14