Effects of root resection and antibacterial drugs on the pulpal and periodontal tissue healing following tooth replantation
Project/Area Number |
26463111
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthodontics/Pediatric dentistry
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Research Institution | Niigata University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
大島 勇人 新潟大学, 医歯学系, 教授 (70251824)
早崎 治明 新潟大学, 医歯学系, 教授 (60238095)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 歯髄幹細胞 / 再生 / 歯根切除 / GFP / 他家移植 / 抗菌性薬剤 |
Outline of Final Research Achievements |
This study aimed to analyze the effects of the enlarged apical foramina on the pulpal healing process using a model for tooth replantation/transplantation. After the extraction of ICR or GFP mouse teeth, the tooth roots from the experimental group were shortened before replantation/transplantation, whereas in the control group the teeth were immediately replanted. The occurrence of abundant tertiary dentin formation was observed in the resected teeth, whereas, divergent healing patterns including dentin, bone, and fibrous tissues were observed in the control group. Tooth transplantation using GFP or wild-type mice demonstrated that the root resection accelerated the revascularization and donor-derived odontoblast-like cell differentiation, resulting in the rapid pulpal healing. In conclusion, the root resection accelerates the dental pulp regeneration following tooth replantation/transplantation due to the better environment for revascularization in the replants.
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Report
(5 results)
Research Products
(20 results)
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[Journal Article] Isolation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers.2017
Author(s)
Murakami T, Saitoh I, Sato M, Inada E, Soda M, Oda M, Domon H, Iwase Y, Sawami T, Matsueda K, Terao Y, Ohshima H, Noguchi H, Hayasaki H
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Journal Title
Archives of Oral Biology
Volume: 81
Pages: 110-120
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Analysis of tooth brushing cycles.2014
Author(s)
Tosaka Y, Nakakura-Ohshima K, Murakami N, Ishii R, Saitoh I, Iwase Y, Yoshihara A, Ohuchi A, Hayasaki H
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Journal Title
Clinical Oral Investigations
Volume: in press
Issue: 8
Pages: 2045-2053
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tooth brushing for oral prophylaxis2014
Author(s)
Hayasaki H, Saitoh I , Nakakura-Ohshima K, Hanasaki M, Nogami Y, Nakajima T, Inada E, Iwasaki T, Iwase Y, Sawami T, Kawasaki K, Murakami N, Murakami T, Kurosawa M, Kimi M, Kagoshima A , Souda M, Yamasaki Y
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Journal Title
Japanese Dental Science Review
Volume: 50
Pages: 69-77
NAID
Related Report
Peer Reviewed
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[Presentation] Observation of chewing and food intake over the course of a meal.2015
Author(s)
Hayasaki H, Murakami N, Murakami T, Saitoh I, Hanasaki M, Nakajima T, Soda M, Nogami Y, Nakakura-Ohshima K, Sawami T, Iwase Y
Organizer
93rd General Session & Exhibition of the IADR
Place of Presentation
Hynes Convention Center, Boston, USA
Year and Date
2015-03-11 – 2015-03-14
Related Report
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[Presentation] Food Intake Volume May Affect Bolus Size during Swallowing.2015
Author(s)
Nakajima T, Saitoh I, Murakami N, Hanasaki M, Murakami T, Iwase Y, Nogami Y, Nakakura-Ohshima K, Hayasaki H
Organizer
93rd General Session & Exhibition of the IADR
Place of Presentation
Hynes Convention Center, Boston, USA
Year and Date
2015-03-11 – 2015-03-14
Related Report
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