Molecular differential inhibition mechanism of osteoclastic bone resorption by glucocorticoid-induced osteop orosis in childhood.
| Project/Area Number |
26463115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
Maki Kenshi 九州歯科大学, 歯学部, 教授 (60209400)
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| Co-Investigator(Kenkyū-buntansha) |
自見 英治郎 九州大学, 歯学研究院, 教授 (40276598)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | osteoclast / p130cas / Bif-1 / PCR / Osteoporosis / 破骨細胞 / Rankl / p130Cas / SH3領域 / ステロイド / 骨粗鬆症 / NF-κB / RANKL / RelB / 骨粗しょう症 / 古典的経路 / ステロイド誘導性骨粗鬆症 / RelB欠損マウス |
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| Outline of Final Research Achievements |
Osteopetrosis due to dysfunction of osteoclasts in p130Cas-deficient mice suggest p130Cas play important roles for osteoclastic bone resorption. we focused Bif-1 which binding p130Cas because of the novelty, primary structure that can be involved in regulation of cytoskeleton. Western blotting and quantitative real-time PCR analysis showed the expression level of Bif-1 increased during osteoclastic differentiation. Bone mineral density of femurs isolated from Bif-1-deficient mice was higher than that of wild-type femurs using μCT analysis. These results suggest that Bif-1 is one of the candidate proteins to regulate osteoclastic bone resorption as a downstream molecule of p130Cas.
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Report
(5 results)
Research Products
(7 results)
