| Project/Area Number |
26463121
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
苅部 洋行 日本歯科大学, 生命歯学部, 教授 (50234000)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 抗腫瘍薬 / 歯の形成不全 / マウス / シクロホスファミド / 晩期合併症 / 小児 / 小児がん / シクロフォスファミド / 歯根形成 |
|---|
| Outline of Final Research Achievements |
In recent decades, improvements in therapies for childhood cancers have increased the number of survivors.However, as the survival rate of children with cancer has improved considerably, the late effects of antineoplastic therapy deserve more attention.In this study, we examined the molar teeth of young mice treated solely with cyclophosphamide(CY), in order to evaluate the effects of CY on root development until occlusion completion. We analyzed morphological changes in the molar roots of mice using 3D structural images to investigate the mechanism underlying the adverse effects of CY on dental root formation. Our results showed that CY administration in the early stages of root formation resulted in impaired root development and early closure of the apical foramen. Additionally, we showed that CY inhibited the regular formation of Hertwig's epithelial root sheath and could cause disturbances to the developing root of the molar.
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