| Project/Area Number |
26463124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Jichi Medical University (2015-2017)
Kanagawa Dental College (2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
久保 金弥 名古屋女子大学, 家政学部, 教授 (00329492)
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| Co-Investigator(Renkei-kenkyūsha) |
Yamamoto Toshiharu 神奈川歯科大学, 歯学部, 准教授 (50111901)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Chewing / ストレス / 扁桃体 / 視床下部室傍核 / p-ERK / カイニン酸 / チューイング / pERK1/2 / p-ERK1/2 / 偏桃体 / p－ERK1/2 |
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| Outline of Final Research Achievements |
The aim of this study was to investigate whether or not a stressed amygdala receives chewing information and projects to the hypothalamic paraventricular nucleus to diminish the cerebral stress response.
Unilaterally ablated GABAergic neurons were induced in male rats by administering anti-GABA-transporter-1-saporin (GAT1-SAP) to the amygdala, and the effects were measured by p-ERK1/2 immunopositive cell profiles in the hypothalamic paraventricular nucleus. Results indicated that in unilaterally ablated rats, chewing’s ameliorating effects were significantly diminished in the stress-induced increase of p-ERK1/2 immunopositive cells in the ipsilateral hypothalamic paraventricular nucleus.
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