Research on biomarkers for periodontitis by measuring reactive oxygen species and proteomics of sliva
| Project/Area Number |
26463125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
Komatsu Tomoko 神奈川歯科大学, 大学院歯学研究科, 講師 (20234875)
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| Co-Investigator(Kenkyū-buntansha) |
李 昌一 神奈川歯科大学, 大学院歯学研究科, 教授 (60220795)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 活性酸素 / 唾液プロテオーム / ヒスタチン / Down 症候群 / 要介護高齢者 / 歯周病 / ダウン症候群 / 唾液タンパク質 / プロテオーム解析 / 電子スピン共鳴法 |
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| Outline of Final Research Achievements |
We investigated periodontitis among young, normal healty individual, young and adult individuals with Down syndorm, and elderly with long-time care were analyzed by scavenging activity of reactive oxygen species (ROS) and proteome on sliva, respectively. Thus, we exmined the relationship between alteration of oral status and ROS scavenging activyty by suportive periodontal therapy and oral cleansing. Combined with oral and general clinical data measured by proteome and change of histatin concentration, which was antioxidant protein, on saliva, we conclued that oxidative stress would contribute to periodontitis and defencive salivary protein individuals with Down syndorm, and elderly with long-time care.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] 施設入所中の40歳以上のダウン症候群の口腔内状況に関する調査2014
Author(s)
植田郁子, 高野知子, 小松知子, 熊田秀文, 坂本貴史, 石井裕美, 岡部愛子, 早野愛, 森田鮎美,高瀬幸子, 井田侑子, 宮城敦, 浜田信城, 池田正一
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Journal Title
障害者歯科
Volume: 35(4),
Pages: 633-639
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Down 症候群患者における唾液プロテオームと歯周病との関連2016
Author(s)
小松知子, 李 昌一, 宮城 敦, 松澤直子, 西山和彦, 石井裕美,岡部愛子, 三國 文,佐久間悠里, 宮本晴美, 森本佳成
Organizer
第33回日本障害者歯科学会学術大会
Place of Presentation
大宮
Year and Date
2016-09-30
Related Report
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