| Project/Area Number |
26463125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
Komatsu Tomoko 神奈川歯科大学, 大学院歯学研究科, 講師 (20234875)
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| Co-Investigator(Kenkyū-buntansha) |
李 昌一 神奈川歯科大学, 大学院歯学研究科, 教授 (60220795)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 活性酸素 / 唾液プロテオーム / ヒスタチン / Down 症候群 / 要介護高齢者 / 歯周病 / ダウン症候群 / 唾液タンパク質 / プロテオーム解析 / 電子スピン共鳴法 |
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| Outline of Final Research Achievements |
We investigated periodontitis among young, normal healty individual, young and adult individuals with Down syndorm, and elderly with long-time care were analyzed by scavenging activity of reactive oxygen species (ROS) and proteome on sliva, respectively. Thus, we exmined the relationship between alteration of oral status and ROS scavenging activyty by suportive periodontal therapy and oral cleansing. Combined with oral and general clinical data measured by proteome and change of histatin concentration, which was antioxidant protein, on saliva, we conclued that oxidative stress would contribute to periodontitis and defencive salivary protein individuals with Down syndorm, and elderly with long-time care.
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