| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
The aim of the present study was to assess if the profiling of citrullination could play a role in the shared mechanisms involved in the pathogenesis of periodontitis and rheumatoid arthritis (RA). The results indicated that the serum antibody responses to peptidylarginine deiminase from Porphyromonas gingivalis (PPAD) were increased in patients with RA as compared to those without RA, which was associated with the expressions of anti-cyclic citrullinated peptide (CCP) antibodies. Additionally, the patients with low anti-PPAD titers showed a greater improvement in RA activities and anti-CCP titers after biological disease-modifying antirheumatic drug (bDMARD) therapy than the patients with high anti-PPAD titers. These results suggest the possibility that the anti-PPAD titers may be related to citrullination and RA, and also affect response to bDMARD in patients with RA.
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