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Molecular basis of amelogenin-induced periodontal tissue regeneration

Research Project

Project/Area Number 26463137
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontology
Research InstitutionKyushu University

Principal Investigator

Fukuda Takao  九州大学, 歯学研究院, 助教 (80507781)

Co-Investigator(Kenkyū-buntansha) 西村 英紀  九州大学, 歯学研究院, 教授 (80208222)
讃井 彰一  九州大学, 大学病院, 講師 (70507780)
武富 孝治  久留米大学, 医学部, 助教 (10553290)
Co-Investigator(Renkei-kenkyūsha) UCHIUMI Takeshi  九州大学, 医学研究院, 准教授 (80253798)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsアメロジェニン / 歯周組織 / 再生 / GRP78 / 歯根膜幹細胞 / マクロファージ / Grp78 / 歯根膜 / Rac1
Outline of Final Research Achievements

Amelogenin, the major component of enamel matrix derivative (Straumann® Emdogain), is well recognized in periodontology. It is used in periodontal surgery to regenerate cementum, periodontal ligament, and alveolar bone. However, the precise molecular mechanisms underlying periodontal regeneration are still unclear.In order to gain further insight into how amelogenin induces periodontal tissue regeneration, we conducted a protein interaction screen using recombinant full-length amelogenin (rM180) as bait. Using this proteomic screen we identified glucose-regulated protein 78 (Grp78) as an amelogenin-binding protein.our study demonstrates that the biological interaction of Grp78 with amelogenin enhances amelogenin-induced cell migration in PDLSCs. Our findings provide a better understanding of the molecular basis of amelogenin-induced periodontal regeneration.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (46 results)

All 2017 2016 2015 2014 Other

All Journal Article (13 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 13 results,  Open Access: 8 results,  Acknowledgement Compliant: 7 results) Presentation (31 results) (of which Int'l Joint Research: 9 results) Remarks (2 results)

  • [Journal Article] Anti-CD14 antibody-treated neutrophils respond to LPS: Possible involvement of CD14 upregulated by anti-CD14 antibody binding.2017

    • Author(s)
      Sanui T, Takeshita M, Fukuda T, Haraguchi A, Aida Y, Nishimura F.
    • Journal Title

      Immunological Investigations

      Volume: 46(2) Issue: 2 Pages: 190-200

    • DOI

      10.1080/08820139.2016.1238925

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Innate immune-stimulatory activity of Porphyromonas gingivalis fimbriae is eliminated by phase separation using Triton X-114.2017

    • Author(s)
      Nozoe K, Sanui T, Takeshita M, Fukuda T, Haraguchi A, Aida Y, Nishimura F.
    • Journal Title

      Journal of Immunological Methods

      Volume: 441 Pages: 31-38

    • DOI

      10.1016/j.jim.2016.11.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation.2017

    • Author(s)
      Takano A, Fukuda T, Shinjo T, Iwashita M, Matsuzaki E, Yamamichi K, Takeshita M, Sanui T, Nishimura F.
    • Journal Title

      Metabolism

      Volume: 69 Pages: 157-170

    • DOI

      10.1016/j.metabol.2017.01.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microarray analysis of the effects of amelogenin on U937 monocytic cells.2017

    • Author(s)
      Sanui T, Fukuda T, Yamamichi K, Toyoda K, Tanaka U, Sangik C, Taketomi T, Nishimura F.
    • Journal Title

      American Journal of Molecular Biology

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Disaggregation of Lipopolysaccharide by Albumin, Hemoglobin, or High Density Lipoprotein, Forming Complexes that Prime Neutrophils for Enhanced Release of Superoxide.2016

    • Author(s)
      Aida Y, Komatsu T, Fukuda T, Sanui T, Hiratsuka S, Pabst M, Nishimura F
    • Journal Title

      Pathogens and Disease

      Volume: 74(3) Pages: ftw003-ftw003

    • DOI

      10.1093/femspd/ftw003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biological Effects of Sprouty2 Inhibition in Periodontal Ligament Cells.2016

    • Author(s)
      Sanui T, Fukuda T, Yamamichi K, Toyoda K, Tanaka U, Taketomi T, Nishimura F.
    • Journal Title

      Journal of Cell Signaling

      Volume: 1 Pages: 1000117-1000117

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] New Therapeutic Strategy for Regenerating Periodontal Tissue Based on the Combination of Amelogenin and Reapplications of Existing Grp78 Inducer.2016

    • Author(s)
      Fukuda T, Sanui T, Toyoda K, Tanaka U, Yamamichi K, Taketomi T, Nishimura F.
    • Journal Title

      Journal of Cell Signaling

      Volume: 1 Pages: 1000118-1000118

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Glucose-Regulated Protein 78: A Novel Therapeutic Target for Amelogenin- Induced Periodontal Tissue Regeneration.2016

    • Author(s)
      Fukuda T, Sanui T, Toyoda K, Tanaka U, Yamamichi K, Taketomi T, Nishimura F.
    • Journal Title

      Single Cell Biology

      Volume: 5 Issue: 2 Pages: 1000137-1000137

    • DOI

      10.4172/2168-9431.1000137

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Grp78 is critical for amelogenin-induced cell migration in a multipotent clonal human periodontal ligament cell line.2016

    • Author(s)
      Toyoda K, Fukuda T, Sanui T*, Tanaka U, Yamamichi K, Atomura R, Maeda H, Tomokiyo A, Taketomi T, Uchiumi T, Nishimura F
    • Journal Title

      Journal of Cellular Physiology

      Volume: 231 Issue: 2 Pages: 414-427

    • DOI

      10.1002/jcp.25087

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibition of Sprouty2 polarizes macrophages toward an M2 phenotype by stimulation with interferon γ and Porphyromonas gingivalis lipopolysaccharide.2016

    • Author(s)
      Atomura R, Sanui T*, Fukuda T, Tanaka U, Toyoda K, Taketomi T, Yamamichi K, Akiyama H, Nishimura F
    • Journal Title

      Immunity, Inflammation and Disease

      Volume: 4(1) Issue: 1 Pages: 98-110

    • DOI

      10.1002/iid3.99

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Sprouty2 inhibition promotes proliferation and migration of periodontal ligament cells.2015

    • Author(s)
      Tanaka U, Sanui T*, Fukuda T, Toyoda K, Atomura R, Yamamichi K, Maeda H, Nishimura F
    • Journal Title

      Oral Diseases

      Volume: 21 Issue: 8 Pages: 977-986

    • DOI

      10.1111/odi.12369

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tyrosine 55 Mutation of Spry2 Induces Proliferation and Differentiation of Osteoblasts through bFGF and EGF Stimulation but Inhibits Proliferation of Gingival Epithelial Cells2015

    • Author(s)
      Sanui T, Tanaka U, Fukuda T, Toyoda K, Taketomi T, Atomura R, Yamamichi K , Nishimura F.
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 116 Issue: 4 Pages: 628-639

    • DOI

      10.1002/jcb.25014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Spry2 is a novel therapeutic target for periodontal tissue regeneration through fibroblast growth factor receptor signaling and epidermal growth factor signaling.2015

    • Author(s)
      Sanui T, Fukuda T, Tanaka U, Toyoda K, Taketomi T, Nishimura F.
    • Journal Title

      Receptors and Clinical Investigation

      Volume: 2

    • DOI

      10.14800/rci.597

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Exosomes From TNF-alpha-treated GMSCs Induce M2 Macrophage Polarization2017

    • Author(s)
      Takao Fukuda, Qunzhou Zhang, Anh Le, Fusanori Nishimura, Songtao Shi
    • Organizer
      2017 IADR/AADR/CADR General Session & Exhibition
    • Place of Presentation
      San Francisco, Calif., USA
    • Year and Date
      2017-03-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨組織におけるアンジオポエチン様タンパク質2の役割の機能解析2016

    • Author(s)
      高野愛子、福田隆男、新城尊徳、岩下未咲、讃井彰一、山道研介、竹下正章、西村英紀
    • Organizer
      第145回日本歯科保存学会2016年度秋季学術大会
    • Place of Presentation
      キッセイ文化ホール、松本市
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Spry2 Downregulation Shifts Macrophages Toward an M2 Phenotype by Stimulation with Interferon γ and Porphyromonas gingivalis Lipopolysaccharide.2016

    • Author(s)
      Terukazu Sanui, Hajime Akiyama, Takao Fukuda, Urara Tanaka, Kyosuke Toyoda, Takaharu Taketomi, Fusanori Nishimura
    • Organizer
      94th General Session & Exhibition of the International Association for Dental Research,
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Grp78 is crucial for cell migration induced by amelogenin in a human periodontal ligament cells.2016

    • Author(s)
      Kyosuke Toyoda, Hajime Akiyama, Takao Fukuda, Terukazu Sanui, Urara Tanaka, Takaharu Taketomi, Fusanori Nishimura
    • Organizer
      94th General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amelogenin Modulates Macrophage Phenotype During Inflammatory Responses.2016

    • Author(s)
      Kensuke Yamamichi, Hajime Akiyama, Takao Fukuda, Terukazu Sanui, Kyosuke Toyoda, Urara Tanaka, Takaharu Taketomi, Fusanori Nishimura
    • Organizer
      94th General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spry2 knockdown enhances proliferation and migration but reduces differentiation of periodontal ligament cells through bFGF and EGF stimulation.2016

    • Author(s)
      Hajime Akiyama, Urara Tanaka, Terukazu Sanui, Takao Fukuda, Kyosuke Toyoda, Kensuke Yamamichi, Takaharu Taketomi, Fusanori Nishimura
    • Organizer
      94th General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨組織におけるアンジオポエチン様タンパク質2の役割の解明2016

    • Author(s)
      高野愛子、福田隆男、新城尊徳、岩下未咲、讃井彰一、山道研介、竹下正章、西村英紀
    • Organizer
      第144回日本歯科保存学会2016年度春季学術大会
    • Place of Presentation
      栃木県総合文化センター、宇都宮市
    • Year and Date
      2016-06-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Molecular basis of amelogenin-induced periodontal tissue regeneration2016

    • Author(s)
      Takao Fukuda, Terukazu Sanui, Kyosuke Toyoda, Urara Tanaka, Kensuke Yamamichi, Ryo Atomura, Hajime Akiyama, Fusanori Nishimura
    • Organizer
      口腔から健康長寿を支えるプロジェクト推進に向けた研究拠点構築プログラム2nd Symposium
    • Place of Presentation
      福岡リーセントホテル
    • Year and Date
      2016-02-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 歯周病感染器官培養モデルを用いた抗菌薬の効果に関する研究2016

    • Author(s)
      竹下正章、原口晃、三浦真由美、濱地貴文、福田隆男、讃井彰一、西村英紀
    • Organizer
      第59日本歯周病学会春季学術大会
    • Place of Presentation
      かごしま県民交流センター・宝山ホール、鹿児島市
    • Related Report
      2016 Annual Research Report
  • [Presentation] Decitabineによる歯周炎モデルマウスにおける歯槽骨吸収抑制効果の検討2016

    • Author(s)
      田中麗、讃井彰一、福田隆男、西村英紀
    • Organizer
      第59回秋季日本歯周病学会学術大会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター、新潟市
    • Related Report
      2016 Annual Research Report
  • [Presentation] アメロジェニンが有する抗炎症効果の機序解明2016

    • Author(s)
      山道研介、福田隆男、讃井彰一、豊田敬介、田中麗、西村英紀
    • Organizer
      平成28年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部・合同研修会
    • Place of Presentation
      長崎県歯科医師会館、長崎市
    • Related Report
      2016 Annual Research Report
  • [Presentation] アメロジェニンが炎症過程におけるマクロファージの形質転換におよぼす影響2015

    • Author(s)
      山道研介、福田隆男、讃井彰一、豊田敬介、後村亮、西村英紀
    • Organizer
      日本歯科保存学会 2015年度秋季学術大会 (143回) 第17回日韓歯科保存学会学術大会
    • Place of Presentation
      文京シビックホール
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒト歯根膜幹細胞/前駆細胞株の細胞遊走時に及ぼす分子機構2015

    • Author(s)
      豊田敬介、福田隆男、讃井彰一、山道研介、後村亮、西村英紀
    • Organizer
      日本歯科保存学会 2015年度秋季学術大会 (143回) 第17回日韓歯科保存学会学術大会
    • Place of Presentation
      文京シビックホール
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Spry2抑制によるM1マクロファージへの分化抑制メカニズムの解析2015

    • Author(s)
      後村亮、讃井彰一、福田隆男、豊田敬介、山道研介、秋山元、西村英紀
    • Organizer
      日本歯科保存学会 2015年度秋季学術大会 (143回) 第17回日韓歯科保存学会学術大会
    • Place of Presentation
      文京シビックホール
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
  • [Presentation] アメロジェニンが有する抗炎症効果の機序解明2015

    • Author(s)
      山道研介、福田隆男、讃井彰一、豊田敬介、後村亮、秋山元、田中麗、西村英紀
    • Organizer
      平成27年度日本臨床歯周病学会九州支部・日本歯周病学会九州五大学合同研修会
    • Place of Presentation
      アクロス福岡
    • Year and Date
      2015-11-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Grp78 Is Critical For Amelogenin-induced Cell Migration In PDLSCs2015

    • Author(s)
      Takao Fukuda, Kyosuke Toyoda, Terukazu Sanui, Urara Tanaka, Kensuke Yamamichi, Ryo Atomura, Takaharu Taketomi, Fusanori Nishimura
    • Organizer
      The 63rd Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Inhibition of Sprouty2 Regulates Cell Functions in Periodontal Ligament Cells2015

    • Author(s)
      Urara Tanaka, Terukazu Sanui, Takao Fukuda, Kyosuke Toyoda, Ryo Atomura, Kensuke Yamamichi, Fusanori Nishimura
    • Organizer
      Penn Periodontal Conference 2015
    • Place of Presentation
      Penn Dental Medicine in Philadelphia, Pennsylvania
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Grp78 is critical for amelogenin-induced cell migration in PDL cells2015

    • Author(s)
      Takao Fukuda, Kyosuke Toyoda, Terukazu Sanui, Urara Tanaka, Kensuke Yamamichi, Ryo Atomura, Takaharu Taketomi, Fusanori Nishimura
    • Organizer
      Penn Periodontal Conference 2015
    • Place of Presentation
      Penn Dental Medicine in Philadelphia, Pennsylvania
    • Year and Date
      2015-06-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Spry2がPorphyromonas gingivalis LPS刺激マクロファージの分化に及ぼす影響について2015

    • Author(s)
      後村亮、讃井彰一、福田隆男、豊田敬介、山道研介、西村英紀
    • Organizer
      日本歯科保存学会 2015年度春季学術大会
    • Place of Presentation
      西日本総合展示場 北九州国際会議場
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Presentation] マクロファージにおけるアメロジェニン刺激の影響の網羅的遺伝子解析2015

    • Author(s)
      山道研介、福田隆男、讃井彰一、豊田敬介、後村亮、西村英紀
    • Organizer
      日本歯科保存学会 2015年度春季学術大会
    • Place of Presentation
      西日本総合展示場 北九州国際会議場
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 歯周病感染器官培養モデルを用いた抗菌薬の効果に関する研究2015

    • Author(s)
      竹下正章、讃井彰一、福田隆男、濱地貴文、西村英紀
    • Organizer
      日本歯科保存学会 2015年度春季学術大会
    • Place of Presentation
      西日本総合展示場 北九州国際会議場
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規に同定したアメロジェニン会合蛋白Grp78がヒト歯根膜幹細胞/前駆細胞株の機能に及ぼす役割の検討2015

    • Author(s)
      豊田敬介、福田隆男、讃井彰一、後村亮、山道研介、田中麗、西村英紀
    • Organizer
      平成27年度 第58回春季日本歯周病学会学術大会
    • Place of Presentation
      幕張メッセ 国際会議場・国際展示場 ホール7
    • Year and Date
      2015-05-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Sprouty2 regulates cell proliferation and migration in periodontal ligament cells2015

    • Author(s)
      Urara Tanaka, Terukazu Sanui, Takao Fukuda, Kyosuke Toyoda, Takaharu Taketomi, Ryo Atomura, Kensuke Yamamichi and Fusanori Nishimura
    • Organizer
      93rd General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Haynes Convention Center, Boston, USA
    • Year and Date
      2015-03-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Grp78 is Essential for Amelogenin-Induced Cell Migration in PDLSCs.2015

    • Author(s)
      T. Fukuda, R. Atomura, T. Kyosuke, K. Yamamichi, U. Tanaka, T. Sanui, T. Taketomi, F. Nishimura
    • Organizer
      93rd General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Haynes Convention Center, Boston, USA
    • Year and Date
      2015-03-15
    • Related Report
      2014 Research-status Report
  • [Presentation] The Effects of Spry2 in Osteoblasts and Gingival Epithelial Cells.2015

    • Author(s)
      T. Sanui, R. Atomura, U. Tanaka, T. Fukuda, K. Toyoda, K.Yamamichi, T. Taketomi, F. Nishimura
    • Organizer
      93rd General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Haynes Convention Center, Boston, USA
    • Year and Date
      2015-03-13 – 2015-03-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Grp78 is critical for amelogenin-induced cell migration in a human periodontal ligament stem/progenitor cell line.2015

    • Author(s)
      Kyosuke Toyoda, Takao Fukuda, Terukazu Sanui, Urara Tanaka,Ryo Atomura, Kensuke Yamamichi, and Fusanori Nishimura
    • Organizer
      Kyudai Oral Bioscience (KOB) 2015
    • Place of Presentation
      福岡リーセントホテル、福岡市
    • Year and Date
      2015-02-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Sprouty2 Regulates Cell Proliferation and Migration in Periodontal Ligament Cells.2015

    • Author(s)
      Urara Tanaka, Terukazu Sanui, Takao Fukuda, Kyosuke Toyoda, Ryo Atomura, Kensuke Yamamichi, and Fusanori Nishimura
    • Organizer
      頭脳循環Kick Off Symposium
    • Place of Presentation
      福岡リーセントホテル、福岡市
    • Year and Date
      2015-02-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Amelogenin induces cell migration via Grp78 in PDL cells.2014

    • Author(s)
      Kyosuke Toyoda, Takao Fukuda, Ryo Atomura, Terukazu Sanui, Urara Tanaka, Takaharu Taketomi, Kensuke Yamamichi and Fusanori Nishimura
    • Organizer
      62nd Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      KKRホテル大阪、大阪市
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Tyrosine 55 Mutation of Spry2 Induces Proliferation and Differentiation of Osteoblasts through bFGF and EGF Stimulation but Inhibits Proliferation of Gingival Epithelial Cells: Implications for Novel Biological Approach to Periodontal Regeneration.2014

    • Author(s)
      Terukazu Sanui, Urara Tanaka, Kyosuke Toyoda, Ryo Atomura, Takao Fukuda, Takaharu Taketomi, Kensuke Yamamichi and Fusanori Nishimura
    • Organizer
      Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      KKRホテル大阪、大阪市
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] アメロジェニンの生物学的活性の機序解明2014

    • Author(s)
      豊田敬介、後村亮、福田隆男、讃井彰一、山道研介、田中麗、西村英紀
    • Organizer
      平成26年度 日本歯周病学会九州五大学日本臨床歯周病学会九州支部合同研修会
    • Place of Presentation
      アクロス福岡、福岡市
    • Year and Date
      2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯周病感染器官培養モデルを用いた抗菌療法確立を目指す基礎研究2014

    • Author(s)
      竹下正章、讃井彰一、福田隆男、濱地貴文、西村英紀
    • Organizer
      平成26年度 日本歯周病学会九州五大学日本臨床歯周病学会九州支部合同研修会
    • Place of Presentation
      アクロス福岡、福岡市
    • Year and Date
      2014-11-16
    • Related Report
      2014 Research-status Report
  • [Remarks] 九州大学歯学研究院口腔機能修復学講座歯周病学分野

    • URL

      http://www.dent.kyushu-u.ac.jp/perio/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 九州大学大学院歯学研究院口腔機能修復学講座歯周病学分野

    • URL

      http://www.dent.kyushu-u.ac.jp/perio/

    • Related Report
      2015 Research-status Report 2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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