| Project/Area Number |
26463138
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
Kaneko Takashi 福岡歯科大学, 口腔歯学部, 教授 (10284697)
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| Co-Investigator(Kenkyū-buntansha) |
原 宜興 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (60159100)
吉村 篤利 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (70253680)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | カスパーゼ１ / IL-1β / NLRP3 / グリブリド / 歯周炎 / 歯周病原細菌 / 骨吸収 / インフラマソーム / カスパーゼ４ / ピロトーシス / 歯周病 / Caspase 1 / Caspase 4 / Caspase 5 / カスパーゼ５ / AIM2 / NLRP1 / NLRC4 |
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| Outline of Final Research Achievements |
Inflammatory cacpases 1,4,5 are involved in production of interleukin-1β and proptosis cell death in inflammatory diseases, and contribute to the clearance of invasive bacterial pathogens. Therefore, we investigated the role of capases in periodontal inflammation in rat experimental periodontal models. We used anti-diabetic drug, gluburide, which is act as NLRP3 inhibitor, to inhibit the activation of caspase 1. The rats given glyburide exhibit significantly lower number of inflammatory cells and osteoclasts and bone resorption compared with control. This results indicate that caspase 1 play an important role in periodontal inflammatory responses and alveolar bone resorption.
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