| Project/Area Number |
26463139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中村 利明 鹿児島大学, 医歯学域附属病院, 講師 (60381183)
町頭 三保 鹿児島大学, 医歯学域附属病院, 講師 (80253897)
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| Co-Investigator(Renkei-kenkyūsha) |
Noguchi Kazuyuki 鹿児島大学, 医歯学域歯学系, 教授 (90218298)
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| Research Collaborator |
Hatae Masayuki 医療法人聖成会, 柿木病院, 副院長
Kamitomo Masato 鹿児島市立病院, 産婦人科, 部長
Kawamata Kazuya 医療法人愛育会, 愛育病院, 副院長
Tateishi Fumi 医療法人社団忠重会, 忠重歯科医院, 歯科医師
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯周病 / 早産 / 低体重児出産 / 歯周病原細菌 / 早産低体重児出産 / 早産・低体重児出産 / porphyromonas gingivalis |
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| Outline of Final Research Achievements |
The bacterial solutions (Pg, Fn, or PgFn) or PBS (Control) were injected into the tail vein of pregnant mice once a day from 8 days at gestation to 10 days at gestation or from 13 days at gestation to 15s day at gestation.
Our results showed that (i) Pg and Fn injected into the tail vein of pregnant mice stayed in placentas, that (ii) the Pg and Fn in placentas involved with growth and development of fetus, and that (iii) the effects of injection of periodontal pathogens from 13 days at gestation to 15 days at gestation were worse than those from 8 days at gestation to 10 days at gestation. In addition, we suggested that (i) the gene expressions of inflammatory mediators in placentas of mice to which periodontal pathogens were injected were tend to higher than those in placentas of control mice and (ii) the gene expressions of inflammatory mediators in placentas of mice to which Fn were injected were most increased in placentas of mice to which periodontal pathogens were injected.
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