Diagnosis and treatments of cardiovascular diseases associated with molecular mimicry between periodontopathic bacteria and ApoH

• Project/Area Number: 26463141
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: Nagasawa Toshiyuki 北海道医療大学, 歯学部, 教授 (90262203)
• Co-Investigator(Kenkyū-buntansha): 辻 昌宏 北海道医療大学, 個体差医療科学センター, 教授 (70364271)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: molecular mimicry / apolipoprotein H / periodontitis / auto-antibody / Porphyromonas gingivalis / A. actinomycetemcomitans / cardiolipin / atherosclerosis / 抗リン脂質抗体症候群 / 歯周炎 / 心臓血管疾患 / 血栓 / Apolipoprotein H / 自己抗体

Outline of Final Research Achievements

Epidemiological studies reported that periodontitis might increase the risk for cardiovascular diseases, but direct mechanisms are remains to be elucidated. We have focused on the molecular mimicry between periodontopathic bacteria and Apolipoprotein H (ApoH, beta 2 glycoprotein I), which inhibit the pathological thrombosis. Our study suggested that periodontal infection might augment the risk for cardiovascular diseases through the induction of auto-antibody that inhibit the function of ApoH.

Research Products

• [Int'l Joint Research] National Taiwan University(Taiwan)
• [Int'l Joint Research] Khon Kaen University(Thailand)
• [Journal Article] リン脂質に対する免疫応答を介した歯周炎と心臓血管疾患の関係 (2016)
  • Author(s): 31. 長澤敏行, 白井 要, 河野 舞, 加藤幸紀, 森 真理, 古市保志
  • Journal Title: 日本歯周病学会会誌 Volume: 58 Pages: 98-106
  • NAID: 130005268282
  • Peer Reviewed
• [Journal Article] A Genome-wide Association Study of Periodontitis in a Japanese Population (2015)
  • Author(s): S. Shimizu, Y. Momozawa, A. Takahashi, T. Nagasawa, K. Ashikawa, Y. Terada, Y. Izumi, H. Kobayashi, M. Tsuji, M. Kubo, and Y. Furuichi
  • Journal Title: Journal of Dental Research Volume: 1 Issue: 4 Pages: 1-7
  • DOI: 10.1177/0022034515570315
  • Peer Reviewed
• [Journal Article] Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease. (2015)
  • Author(s): Wang CY, Chyuan IT, Wang YL, Kuo MY, Chang CW, Wu KJ, Hsu PN, Nagasawa T, Wara-Aswapati N, Chen YW.
  • Journal Title: Journal of Periodontology Volume: 30 Issue: 8 Pages: 995-1004
  • DOI: 10.1902/jop.2015.140664
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease. (2015)
  • Author(s): Wang CY, Chyuan IT, Wang YL, Kuo MY, Chang CW, Wu KJ, Hsu PN, Nagasawa T, Wara-Aswapati N, Chen YW.
  • Journal Title: J Periodontol Volume: 30 Pages: 1-25
  • Peer Reviewed
• [Journal Article] Inhibitory effects of sword bean extract on alveolar bone resorption induced in rats by Porphyromonas gingivalis infection. (2014)
  • Author(s): Nakatsuka Y, Nagasawa T, Yumoto Y, Nakazawa F, Furuichi Y.
  • Journal Title: J Periodontal Res Volume: 49 Issue: 6 Pages: 801-9
  • DOI: 10.1111/jre.12166
  • Peer Reviewed
• [Journal Article] Host–microbial co-evolution in periodontitis associated with Aggregatibacter actinomycetemcomitans infection (2014)
  • Author(s): Nagasawa T, Shimizu S, Kato S, Nakatsuka Y, Kado T, Hidaka T, Shirai K, Mori M, Furuichi Y
  • Journal Title: J Oral Biosci Volume: 49 Pages: 11-17
  • Peer Reviewed
• [Presentation] 歯科からみた糖尿病合併症対策 (2015)
  • Author(s): 長澤敏行
  • Organizer: 日本口腔検査学会
  • Place of Presentation: 神奈川歯科大学大講堂
  • Year and Date: 2015-10-03
  • Invited
• [Presentation] 日本人歯周炎患者のゲノムワイド関連解析 (2015)
  • Author(s): 98. 清水伸太郎, 古市保志, 久保充明,桃沢幸秀, 高橋篤, 長澤敏行, 芦川享題, 寺田裕, 和泉雄一, 小林宏明, 辻昌宏
  • Organizer: 日本歯周病学会学術大会
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2015-09-12
• [Presentation] 唾液中の歯周病原細菌と血清抗酸化物質の関係 (2015)
  • Author(s): 渡邉裕之,長澤敏行, 加藤幸紀, 寺田 裕, 辻 昌宏, 古市保志
  • Organizer: 日本歯周病学会学術大会
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2015-09-12
• [Presentation] 高脂血症患者における高感度CRPに対する歯周病の影響 (2014)
  • Author(s): 寺田 裕、長澤敏行、小西ゆみ子、森 真理、舞田健夫、川上智史、井出 肇、辻 昌宏、古市保志
  • Organizer: 第57回春季日本歯周病学会学術大会
  • Place of Presentation: 長良川国際会議場、岐阜都ホテル
  • Year and Date: 2014-05-22 – 2014-05-24