Development of Periodontal Disease Rapid Diagnostic System using Occult Blood in GCF
| Project/Area Number |
26463146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 弘 日本歯科大学, 生命歯学部, 准教授 (30184683)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯肉溝滲出液(GCF) / 歯周組織検査 / 遊離ヘモグロビン(Hb) / 炎症 / イムノクロマト法 / 潜血 / 歯肉溝滲出液 (GCF) / 遊離ヘモグロビン / IC（イムノクロマト）法 / ルミノール法 / ヘモグロビン |
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| Outline of Final Research Achievements |
For the development of periodontal disease rapid diagnostic system, we focused on the occult bleeding (hemoglobin) in gingival crevicular fluid (GCF). We employed the gingival healthy person and the periodontal disease patient at our hospital and performed the following examination.
1) Investigate the association between quantity of hemoglobin in GCF and the condition of periodontal tissue, 2)Development of the rapid diagnostic kit which can detect a occult bleeding (hemoglobin) in GCF, 3) Making the guideline of periodontal disease rapid diagnostic kit for detect an initial stage of periodontal disease.
We improved the hemoglobin detection kit for fecal occult-blood in medical examinations which apply an immunochromatographic analysis method. We also examined a convenience and sensitivity of this kit, we succeeded in the development of the periodontal disease rapid diagnostic system.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Correlation Between Gingival Crevicular Fluid Hemoglobin Content and Periodontal Clinical Parameters.2016
Author(s)
Ito H, Numabe Y, Hashimoto S, Sekino S, Murakashi E, Ishiguro H, Sasaki D, Yaegashi T, Takai H, Mezawa M, Ogata Y, Watanabe H, Hagiwara S, Izumi Y, Hiroshima Y, Kido JI, Nagata T, Kunimatsu K.
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Journal Title
Journal of Periodontology
Volume: 87
Issue: 11
Pages: 1314-1319
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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