Effects of periodontal disease via serum amyloid A on aging on the mechanism of exacerbation of arteriosclerosis
Project/Area Number |
26463148
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontology
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Research Institution | Matsumoto Dental University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
小出 雅則 松本歯科大学, 総合歯科医学研究所, 講師 (10367617)
武藤 昭紀 松本歯科大学, 歯学部, 講師 (50549433)
田口 明 松本歯科大学, 歯学部, 教授 (70243582)
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Research Collaborator |
TAKAHASHI KOTAROU 松本歯科大学, 歯学部, 大学院生
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 歯周炎 / 心臓血管疾患 / 老化 |
Outline of Final Research Achievements |
The purpose of this study is through searching the aging effect on Human Aortic Endothelial Cells (HAECs) by serum amyloid A (SAA) stimulation, to find the mechanism to biological aging through SAA from periodontal disease via aggravation of atherosclerosis. The donor stimulated two kinds of HAECs, 21 years old and 81 years old, with SAA and confirmed the expressed SAA receptor gene, and the expression of TLR2 was remarkable in both donors. In addition, adhesion molecules were strongly expressed in HAECs of 81-year-old donor, therefore, inflammatory response was stronger in HAECs of the elderly. Furthermore, in the HAECs experimental group of the 81-year-old donor, many positive cells were found by SA-βGal staining. From these results, it was supposed that SAA administration induced inflammatory responses and aging responses in the aortic vascular endothelial cells of the elderly via TLR2.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Polarization of osteoclasts on dental implant materials is similar to that observed on bone.2014
Author(s)
Nakayama T., Thirukonda G. J., Nagasawa S., Kawahara I, Udagawa N., Yagami K., Kawatani M., Osada H., Doi Y., Yoshinari N., and Takahashi N.
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Journal Title
J. Oral Biosci.
Volume: 56
Issue: 4
Pages: 136-142
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The effect of serum amyloid A for endothelial cell.2016
Author(s)
Nobuo Yoshinari, Kotaro Takahashi, Kiyohito Kaise, Murtaza Saleem, Yuki Ozaki, Suguru Nakamura, Keita Kubokawa, Yuichi Ishihara
Organizer
The 94th Annual Meeting of International Association for Dental Research
Place of Presentation
COEX Convention Center(Seoul, Korea)
Year and Date
2016-06-24
Related Report
Int'l Joint Research
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[Presentation] 最新の歯周病事情2015
Author(s)
吉成伸夫
Organizer
平成27年度愛知県歯科衛生士研修会
Place of Presentation
ウイル愛知(名古屋)
Year and Date
2015-11-01
Related Report
Invited
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