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Potential role of IL-1 family cytokines in periodontal diseases

Research Project

Project/Area Number 26463150
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontology
Research InstitutionOsaka Medical College (2016)
Hyogo Medical University (2014-2015)

Principal Investigator

Ohyama Hideki  大阪医科大学, 医学部, 非常勤講師 (90280685)

Co-Investigator(Kenkyū-buntansha) 中正 恵二  兵庫医科大学, 医学部, 教授 (00217712)
山根木 康嗣  兵庫医科大学, 医学部, 講師 (00434944)
山田 直子  兵庫医科大学, 医学部, 講師 (10319858)
久保 秀司  兵庫医科大学, 医学部, 准教授 (10441320)
小越 菜保子  大阪医科大学, 医学部, 助教 (60509115)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsIL-36 / 歯肉上皮細胞 / 歯周病 / IL-36
Outline of Final Research Achievements

We evaluated the expression of IL-1 family cytokines in the periodontal tissue of periodontitis patients. We focused on the expression of IL-36γ as it was found to be highly expressed in the gingival epithelium. We found that the expression of IL-36γ in gingival epithelial cells was significantly induced by IL-1β, TNF-α, IL-17, and Porphyromonas gingivalis. In addition, the IL-36γ expression level increased with differentiation of gingival epithelial cells. These results suggest the potential role of IL36γ in periodontal diseases.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] Functional analysis of differences in transcriptional activity conferred by genetic variants in the 5' flanking region of the IL12RB2 gene.2016

    • Author(s)
      Kato-Kogoe N, Ohyama H, Okano S, Yamanegi K, Yamada N, Hata M, Nishiura H, Abiko Y, Terada N, Nakasho K
    • Journal Title

      Immunogenetics

      Volume: 68(1) Issue: 1 Pages: 55-65

    • DOI

      10.1007/s00251-015-0882-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Expression of interleukin-34 and colony stimulating factor-1 in the stimulated periodontal ligament cells with tumor necrosis factor-α.,2015

    • Author(s)
      Kawabe M, Ohyama H, Kato-Kogoe N, Yamada N, Yamanegi K, Nishiura H, Hirano H, Kishimoto H, Nakasho K.
    • Journal Title

      Med Mol Morphol.

      Volume: -

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Expression of interleukin-34 and colony stimulating factor-1 in the stimulated periodontal ligament cells with tumor necrosis factor-α2014

    • Author(s)
      Kawabe M, Ohyama H, Kato-Kogoe N, Yamada N, Yamanegi K, Nishiura H, Hirano H, Kishimoto H, Nakasho K.
    • Journal Title

      Med Mol Morphol

      Volume: 25 Issue: 3 Pages: 54-68

    • DOI

      10.1007/s00795-014-0094-8

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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