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Effect of IL-22 on immune response against periodontal bacteria

Research Project

Project/Area Number 26463151
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontology
Research InstitutionOsaka Medical College (2016)
Hyogo Medical University (2014-2015)

Principal Investigator

Kato-kogoe Nahoko  大阪医科大学, 医学部, 助教 (60509115)

Co-Investigator(Kenkyū-buntansha) 大山 秀樹  兵庫医科大学, 医学部, 非常勤講師 (90280685)
中山 真彰  岡山大学, 医歯薬学総合研究科, 助教 (10579105)
山根木 康嗣  兵庫医科大学, 医学部, 講師 (00434944)
山田 直子  兵庫医科大学, 医学部, 講師 (10319858)
黒田 義弘  姫路獨協大学, 薬学部, 特別教授 (90093236)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsIL-22 / 歯肉上皮細胞 / 細胞内侵入細菌 / IL-22 / 歯周病 / P.gingivalis / 歯周病細菌 / 抗菌ペプチド
Outline of Final Research Achievements

This study focused on the effects of IL-22 on the response against periodontal bacteria in gingival epithelial cells. We found that IL-22 reduced gingival epithelial cell differentiation and subsequently decreased antibiotic peptide productivity. In addition, incubation with IL-22 decreased the invasion of Porphyromonas gingivalis into the gingival epithelial cells. The results suggest that IL-22 augments resistance to bacterial invasion of gingival epithelial cells.
The effect of IL-22 on immune response against periodontal bacteria.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results)

  • [Journal Article] Functional analysis of differences in transcriptional activity conferred by genetic variants in the 5' flanking region of the IL12RB2 gene.2016

    • Author(s)
      Kato-Kogoe N, Ohyama H, Okano S, Yamanegi K, Yamada N, Hata M, Nishiura H, Abiko Y, Terada N, Nakasho K
    • Journal Title

      Immunogenetics

      Volume: 68(1) Issue: 1 Pages: 55-65

    • DOI

      10.1007/s00251-015-0882-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Suppressive effect of membrane-permeable peptides derived from autophosphorylation sites of the IGF-1 receptor on breast cancer cells.2015

    • Author(s)
      Kuroda Y, Kato-Kogoe N, Tasaki E, Yuasa-Sunagawa M, Yamanegi K, Nakasyo K, Nakase I, Futaki S, Tohyama Y, Hirose M
    • Journal Title

      European Journal of Pharmacology

      Volume: 765 Pages: 24-33

    • DOI

      10.1016/j.ejphar.2015.08.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells.2015

    • Author(s)
      Yamanegi K, Kawabe M, Futani H, Nishiura H, Yamada N, Kato-Kogoe N, Kishimoto H, Yoshiya S, Nakasho K.
    • Journal Title

      Int J Oncol

      Volume: 46 Issue: 5 Pages: 1994-2002

    • DOI

      10.3892/ijo.2015.2924

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of interleukin-34 and colony stimulating factor-1 in the stimulated periodontal ligament cells with tumor necrosis factor-α2014

    • Author(s)
      Kawabe M, Ohyama H, Kato-Kogoe N, Yamada N, Yamanegi K, Nishiura H, Hirano H, Kishimoto H, Nakasho K.
    • Journal Title

      Med Mol Morphol

      Volume: 25 Issue: 3 Pages: 54-68

    • DOI

      10.1007/s00795-014-0094-8

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Annexin A3 plays a role in cytoplasmic calcium oscillation by extracellular calcium in the human promyelocytic leukaemia HL-60 cells differentiated by phorbol-12-myristate-13-acetate2014

    • Author(s)
      Hiroshi Nishiura, Koji Yamanegi, Mutsuki Kawabe, Nahoko Kato-Kogoe, Naoko Yamada, Keiji Nakasho
    • Journal Title

      Experimental and Molecular Pathology

      Volume: 97 Issue: 2 Pages: 241-246

    • DOI

      10.1016/j.yexmp.2014.07.010

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

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Published: 2014-04-04   Modified: 2018-03-22  

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