| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Saliva contains many bioactive substances, and holds promise for use in clinical tests thanks to its ability to be sampled conveniently and non-invasively compared with blood. In this study, the concentration ranges of bioactive substances in saliva sampled from periodontally healthy or gingivitis patients were determined and analyzed in detail to develop a novel technique for diagnosing periodontal inflammation using saliva specimens. Saliva and gingival crevicular fluid (GCF) were collected from healthy adults, with periodontal tissue ranging in condition from healthy to gingivitis. Relations were characterized between the concentration ranges of several biomarkers, the abundance ratios and concentration ranges of salivary cytokines, and periodontal inflammatory state. The basic research data obtained will help to develop new saliva or GCF-based procedures for use in health check-ups.
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