| Project/Area Number |
26463169
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Oseko Fumishige 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10398406)
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| Co-Investigator(Kenkyū-buntansha) |
山本 俊郎 京都府立医科大学, 医学(系)研究科(研究院), 講師 (40347472)
喜多 正和 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60153087)
金村 成智 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (70204542)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 粘膜炎 / カルテノイド / 抗がん剤 |
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| Outline of Final Research Achievements |
The expressions of inflammatory cytokines in the cells of oral mucosa stimulated by 5FU were increased. In additon of β-cry, the increase of inflammatory cytokines by the stimulation of 5FU was suppressed. The results shows that β-cry may have anti-inflammatory effects on the oral mucosa, may be usable as therapeutic agent for inflammatory diseases in the oral mucosa. the working mechanism of the increase of inflammatory cytokines was an activation of ERK that participates in signal transduction in the cells stimulated by 5FU. In additon of β-cry, the activation of ERK was suppressed and we think that results in the suppression of inflammatory cytokines. Beta-cry may have anti-inflammatory effects on the oral mucosa. Thus, β-cry may have anti-inflammatory effects on the oral mucosa. Thus, β-cry derived from natural food may serve as a safe therapeutic agent for inflammatory diseases in the oral mucosa.
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