Effects of Hydrogen-rich water on aphthous stomatitis
| Project/Area Number |
26463172
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小林 良喜 日本大学, 松戸歯学部, 助手(専任扱) (10609085)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 水素水 / 口内炎モデルラット / 口内炎 / 口腔粘膜炎 / 抗酸化物質 / 抗炎症効果 / 酸化ストレス |
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| Outline of Final Research Achievements |
Hydrogen (H2) water may be applied to prevent the stomatitis since it inhibits the inflammation via decrease in interleukin 6 (IL6). We established the new rat model of the stomatitis and researched the effect of H2 water on the stomatitis using its model. The stomatitis was induced on the rat tongue. H2 or de-H2 water were applied to the rat for 8 days since a week ago of stomatitis induction. At 24 h after the stomatitis induction, mRNA levels of the inflammatory cytokines were measured by the real-time PCR. IL6 mRNA level was decreased by the treatment of H2 water.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss2015
Author(s)
Bhawal UK, Lee HJ, Arikawa K, Shimosaka M, Suzuki M, Toyama T, Sato T, Kawamata R, Taguchi C, Hamada N, Nasu I, Arakawa H, Shibutani K
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Journal Title
International Journal of Oral Science
Volume: 7(4)
Issue: 4
Pages: 242-249
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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