Effects of Hydrogen-rich water on aphthous stomatitis

• Project/Area Number: 26463172
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Nihon University
• Principal Investigator: ARIKAWA Kazumune 日本大学, 松戸歯学部, 准教授 (50318325)
• Co-Investigator(Kenkyū-buntansha): 小林 良喜 日本大学, 松戸歯学部, 助手(専任扱) (10609085)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 水素水 / 口内炎モデルラット / 口内炎 / 口腔粘膜炎 / 抗酸化物質 / 抗炎症効果 / 酸化ストレス

Outline of Final Research Achievements

Hydrogen (H2) water may be applied to prevent the stomatitis since it inhibits the inflammation via decrease in interleukin 6 (IL6). We established the new rat model of the stomatitis and researched the effect of H2 water on the stomatitis using its model. The stomatitis was induced on the rat tongue. H2 or de-H2 water were applied to the rat for 8 days since a week ago of stomatitis induction. At 24 h after the stomatitis induction, mRNA levels of the inflammatory cytokines were measured by the real-time PCR. IL6 mRNA level was decreased by the treatment of H2 water.

Research Products

• [Journal Article] Phenytoin-induced gingival overgrowth caused by death receptor pathway malfunction (2017)
  • Author(s): Reiri Takeuchi，Koichi Hiratsuka，Kazumune Arikawa，Makiko Ono，Masamichi Komiya，Yoshiaki Akimoto， Akira Fujii，Hiroko Matsumoto
  • Journal Title: Oral Diseases Volume: 24 Issue: 5 Pages: 319-324
  • DOI: 10.1111/odi.12651
  • Peer Reviewed / Open Access
• [Journal Article] 納豆食による自然免疫誘導の検討 (2017)
  • Author(s): 小林良喜，田口千恵子，有川量崇，内山敏一，齊藤孝親，落合智子
  • Journal Title: 日大口腔科学 Volume: 43 Pages: 41-47
  • NAID: 40021165220
  • Peer Reviewed
• [Journal Article] Micromolar Levels of Sodium Fluoride Promote Osteoblast Differentiation Through Runx2 Signaling (2017)
  • Author(s): Masahiro Lee，Kazumune Arikawa，Fumio Nagahama
  • Journal Title: Biological trace element research Volume: in press Issue: 2 Pages: 1-9
  • DOI: 10.1007/s12011-017-0930-5
  • Peer Reviewed / Open Access
• [Journal Article] 歯科診療室内の浮遊微粒子群がTHP-1細胞に与える影響 (2017)
  • Author(s): 田口千恵子，小林良喜，加藤志奈，有川量崇，内山敏一，那須郁夫
  • Journal Title: 日大口腔科学 Volume: 43 Pages: 35-40
  • NAID: 40021165145
  • Peer Reviewed
• [Journal Article] Possible pharmacotherapy for nifedipine-induced gingival overgrowth: 18α-glycyrrhetinic acid inhibits human gingival fibroblast growth (2016)
  • Author(s): Reiri Takeuchi, Koichi Hiratsuka, Kazumune Arikawa, Makiko Ono, Masamichi Komiya, Yoshiaki Akimoto, Akira Fujii, Hiroko Matsumoto
  • Journal Title: British Journal of Pharmacology Volume: 173 Issue: 5 Pages: 913-924
  • DOI: 10.1111/bph.13410
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] <b>Circadian Rhythm Affects the Dynamics of S-IgA Mucosal Secretion </b> (2015)
  • Author(s): Ryoki Kobayashi，Chieko Taguchi，Shusuke Yonenaga，Kazumune Arikawa，Toshikazu Uchiyama，Tetsuro Kono，Takashi Takeuchi，Ikuo Nasu，Hirohiko Hirano，Tomoko Ochiai
  • Journal Title: International Journal of Oral-Medical Sciences Volume: 14 Issue: 1 Pages: 1-7
  • DOI: 10.5466/ijoms.14.1
  • NAID: 130005099990
  • ISSN: 1347-9733, 2185-4254
  • Peer Reviewed
• [Journal Article] Influence of Low Level Sodium Fluoride on Expression of IGF-1 and IGF-2 Protein in Experimental Type 2 Diabetes with Periodontitis Model (2015)
  • Author(s): Hye-Jin Lee，Kazumune Arikawa
  • Journal Title: Journal of Hard Tissue Biology Volume: 24 Issue: 4 Pages: 319-324
  • DOI: 10.2485/jhtb.24.319
  • NAID: 130005104340
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed
• [Journal Article] 歯科保健サービスが実施されている介護老人福祉施設の環境要因 (2015)
  • Author(s): 和田康志，池田和博，有川量崇，平野浩彦，大久保一郎
  • Journal Title: 日本歯科医療管理学会雑誌 Volume: 50 Pages: 118-124
  • Peer Reviewed
• [Journal Article] 多項目・短時間唾液検査システム（AL-55）の口臭評価における有用性 (2015)
  • Author(s): 長濱文雄，田中宏征，内山敏一，有川量崇，田口千恵子，横田容子，牧村英樹，景山万貴子，藤田光，木本統，河野善治，福本雅彦
  • Journal Title: 日本歯科人間ドック学会誌 Volume: 10 Pages: 36-44
  • Peer Reviewed
• [Journal Article] <b>Orally Ingested </b><b><i>Lactobacillus crispatus </i></b><b>KT-11 Inhibits </b><b><i>Porphyromonas gingivalis</i></b><b>infected Alveolar Bone Resorption </b> (2015)
  • Author(s): Chieko Taguchi，Kazumune Arikawa，Masanori Saitou，Toshikazu Uchiyama，Itsuki Watanabe，Keisuke Tobita，Ryoki Kobayashi，Tomoko Ochiai，Ikuo Nasu
  • Journal Title: International Journal of Oral-Medical Sciences Volume: 13 Issue: 3 Pages: 102-109
  • DOI: 10.5466/ijoms.13.102
  • NAID: 130005076109
  • ISSN: 1347-9733, 2185-4254
  • Peer Reviewed
• [Journal Article] Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss (2015)
  • Author(s): Bhawal UK, Lee HJ, Arikawa K, Shimosaka M, Suzuki M, Toyama T, Sato T, Kawamata R, Taguchi C, Hamada N, Nasu I, Arakawa H, Shibutani K
  • Journal Title: International Journal of Oral Science Volume: 7(4) Issue: 4 Pages: 242-249
  • DOI: 10.1038/ijos.2015.28
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 口腔環境といびきの関連性―市川市(千葉県)における口腔診査とアンケート調査結果― (2015)
  • Author(s): 有川量崇，田口千恵子，鈴木浩司，石井広志，千葉和成，長谷川勝，内山敏一，小林良喜，伊藤誠康，竹内麗理，永岡明記，小椋正之，和田康志，那須郁夫
  • Journal Title: 日本歯科医療管理学会雑誌 Volume: 49 Pages: 200-209
  • Open Access
• [Journal Article] <b>Enhancement of Antimicrobial Peptide Induction in Both Oral and Intestinal Mucosa by Fermented Daily Products</b> (2014)
  • Author(s): Kazumune Arikawa，Ryoki Kobayashi，Ryoko Kurisu，Chieko Taguchi，
  • Journal Title: International Journal of Oral-Medical Sciences Volume: 12 Issue: 4 Pages: 225-229
  • DOI: 10.5466/ijoms.12.225
  • NAID: 130004679801
  • ISSN: 1347-9733, 2185-4254
  • Peer Reviewed / Open Access
• [Journal Article] Patient satisfaction survey at the Dental Human Dock Clinic of Nihon University School of Dentistry at Matsudo Hospital (2014)
  • Author(s): Toshikazu Uchiyama，Hiroyuki Tanaka，Kazumune Arikawa，Megumi Fuse，Yoko Yokota，Nobuyuki Kikuchi，Chikako Nishitani，Hideki Makimura，Fumio Nagahama，Akira Fukatsu，Yoshiharu Kono，Masahiko Fukumoto，and Moriyasu Wada
  • Journal Title: Int J Oral-Med Sci Volume: 13 Pages: 45-52
  • NAID: 130005130356
  • Peer Reviewed / Open Access
• [Journal Article] Biomechanical Loading Evaluation of Unsintered Hydroxyapatite/poly-L-lactic Acid Plate in Bilateral Sagittal Split Ramus Osteotomy (2014)
  • Author(s): 中久木康一，黒原一人，有川量崇，原田清
  • Journal Title: The Japanese Journal of Jaw Deformities Volume: 24 Issue: 3 Pages: 211-217
  • DOI: 10.5927/jjjd.24.211
  • NAID: 130004691911
  • ISSN: 0916-7048, 1884-5045
  • Peer Reviewed / Open Access
• [Journal Article] 高齢者におけるプロタミン分解ペプチドの舌苔蓄積予防効果 (2014)
  • Author(s): 有川量崇，田口千恵子，小林良喜，竹内麗理，谷野 弦，内山敏一，榎本みど理，伊藤誠康，河野善治，福本雅彦，中久木康一，久保山昇，那須郁夫
  • Journal Title: 日本歯科人間ドック学会誌 Volume: 9 Pages: 36-44
  • Peer Reviewed / Open Access
• [Journal Article] 犬の口臭に対するPMTC効果 (2014)
  • Author(s): 有川量崇，内山敏一，田口千恵子，有川路子，続橋治，久保山昇，西山典宏，根本君也，河野善治，那須郁夫，前田隆秀
  • Journal Title: 日本総合口腔医療学会雑誌 Volume: 1 Pages: 24-35
  • Peer Reviewed / Open Access
• [Journal Article] 東日本大震災後の居住環境による歯と口の健康への影響に関する調査報告 (2014)
  • Author(s): 中久木康一，木村裕，菅原諭子，有川量崇，佐藤由理
  • Journal Title: 社会医学研究 Volume: 31 Pages: 31-40
  • Peer Reviewed / Open Access
• [Presentation] ラットによる口内炎モデルの開発 (2017)
  • Author(s): 田口千恵子，竹内麗理，有川量崇，内山敏一，河野善治，那須郁夫，平塚浩一
  • Organizer: 第18回日本口腔機能水学会学術大会
  • Place of Presentation: 日本大学歯学部（東京都文京区）
  • Year and Date: 2017-03-11
• [Presentation] 口内炎モデルラットによる水素水の治療および予防効果の検討 (2016)
  • Author(s): 竹内麗理, 有川量崇, 田口千恵子, 中山竜司, 平塚浩一, 那須郁夫
  • Organizer: 第65回日本口腔衛生学会総会
  • Place of Presentation: 東京医科歯科大学（東京都文京区）
  • Year and Date: 2016-05-27
• [Presentation] マウスにおける分泌型IgA抗体産生の概日リズム (2016)
  • Author(s): 田口千恵子, 小林良喜, 有川量崇, 中山竜司, 落合智子, 那須郁夫
  • Organizer: 第65回日本口腔衛生学会総会
  • Place of Presentation: 東京医科歯科大学（東京都文京区）
  • Year and Date: 2016-05-27
• [Presentation] 口内炎モデルラットによる水素水の治療および予防効果の検討 (2016)
  • Author(s): 竹内麗理，有川量崇，田口千恵子，平塚浩一，那須郁夫
  • Organizer: 第65回日本口腔衛生学会・総会
  • Place of Presentation: 東京医科歯科大学（東京都文京区）
  • Year and Date: 2016-05-27
• [Presentation] 納豆摂取による歯肉粘膜からの抗菌ペプチドの発現 (2014)
  • Author(s): 有川量崇，小林良喜，田口千恵子，中山竜司，生田明敏，落合智子，那須郁夫
  • Organizer: 第63回日本口腔衛生学会総会
  • Place of Presentation: 熊本市民会館（熊本市）
  • Year and Date: 2014-05-29 – 2014-05-31
• [Presentation] 発酵食品（納豆）による口腔免疫賦活効果 (2014)
  • Author(s): 小林良喜，有川量崇，田口千恵子，那須郁夫，落合智子
  • Organizer: 第63回日本口腔衛生学会総会
  • Place of Presentation: 熊本市民会館（熊本市）
  • Year and Date: 2014-05-29 – 2014-05-31
• [Presentation] 特別支援学校におけるフッ化物洗口普及事業の取組みについて (2014)
  • Author(s): 田口千恵子，有川量崇，馬場俊郎，内山敏一，後藤田宏也，那須郁夫
  • Organizer: 第63回日本口腔衛生学会総会
  • Place of Presentation: 熊本市民会館（熊本市）
  • Year and Date: 2014-05-29 – 2014-05-31