Relationship between recovering mastication activity and improvement of the metabolic syndrome under the time-dependent of the identical experiment animal
| Project/Area Number |
26463173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松本 邦史 鹿児島大学, 医歯学域附属病院, 講師 (00508658)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 咀嚼 / 顎関節 / メタボリックシンドローム / OVX / マイクロCT |
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| Outline of Final Research Achievements |
This study aimed to assess the time-dependent influence of the reduction of mastication activity on amount of visceral fat and bone morphology of the temporomandibular joint (TMJ) in an ovariectomised rat as an elderly female model and adolescent rats. Grinding edges of the upper and lower incisors of rats reduced tooth attrition of the molar in the experimental group and was considered as a mastication reduced rat model. There was no difference in amount of visceral fat and neutral fat in the blood between control and experimental groups in both elderly and adolescent rats. Reduction of appropriate mastication activity in the growth period immediately induces poor growth of the mandibular condyle. Atrophic changes of the mandibular condyle of the TMJ could arise even in an elderly female with normal masticatory function. Reduction of appropriate mastication activity in the elderly female population is a risk factor for inducing severe atrophy of the mandibular condyle.
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Report
(4 results)
Research Products
(5 results)
