Relationship between recovering mastication activity and improvement of the metabolic syndrome under the time-dependent of the identical experiment animal

• Project/Area Number: 26463173
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Nihon University
• Principal Investigator: ARAI Yoshinori 日本大学, 歯学部, 教授 (20212607)
• Co-Investigator(Kenkyū-buntansha): 松本 邦史 鹿児島大学, 医歯学域附属病院, 講師 (00508658)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 咀嚼 / 顎関節 / メタボリックシンドローム / OVX / マイクロCT

Outline of Final Research Achievements

This study aimed to assess the time-dependent influence of the reduction of mastication activity on amount of visceral fat and bone morphology of the temporomandibular joint (TMJ) in an ovariectomised rat as an elderly female model and adolescent rats. Grinding edges of the upper and lower incisors of rats reduced tooth attrition of the molar in the experimental group and was considered as a mastication reduced rat model. There was no difference in amount of visceral fat and neutral fat in the blood between control and experimental groups in both elderly and adolescent rats. Reduction of appropriate mastication activity in the growth period immediately induces poor growth of the mandibular condyle. Atrophic changes of the mandibular condyle of the TMJ could arise even in an elderly female with normal masticatory function. Reduction of appropriate mastication activity in the elderly female population is a risk factor for inducing severe atrophy of the mandibular condyle.

Research Products

• [Presentation] 咀嚼機能の低下が下顎頭に与える影響：ラット実験モデルによる経時的評価 (2017)
  • Author(s): 松本邦史、鈴木敏浩、新井嘉則、本田和也
  • Organizer: NPO法人 日本歯科放射線学会 第58回学術大会
  • Place of Presentation: かごしま県民交流センター（鹿児島県鹿児島市）
  • Year and Date: 2017-06-02
• [Presentation] Reduction of mastication activity induces hypotrophy of the mandibular condyle in an OVX animal model: Microcomputed tomography analysis in an experimental animal model (2016)
  • Author(s): Kunihito Matsumoto, Toshihiro Suzuki, Yoshinori Arai, Kazuya Honda
  • Organizer: The 11th ACOMFR Asian Congress of Oral and Maxillo Facial Radiology
  • Place of Presentation: Chiang Mai (Tai land)
  • Year and Date: 2016-11-10
  • Int'l Joint Research
• [Presentation] Reduction of mastication activity induces hypotrophy of the mandibular condyle: Micro-computed tomography analysis in an experimental animal model (2016)
  • Author(s): Matsumoto K, Suzuki T, Arai Y, Honda K
  • Organizer: ECDMFR2016
  • Place of Presentation: City Hall, Cardiff, UK
  • Year and Date: 2016-06-15
• [Presentation] 咀嚼能力低下による下顎頭の退行性変化：高齢モデルラットを用いたin vivo研究 (2015)
  • Author(s): 松本邦史，鈴木敏浩，小日向清美，新井嘉則，本田和也
  • Organizer: 第28回日本顎関節学会総会・学術大会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-07-04
• [Presentation] 加齢モデルラットの咀嚼能力低下による下顎頭の変化：“よく噛めない”と顎関節形態は退行する (2015)
  • Author(s): 松本邦史，鈴木敏浩，新井嘉則，本田和也
  • Organizer: 第56回日本歯科放射線学会学術大会
  • Place of Presentation: 仙台戦災復興記念館（宮城県仙台市）
  • Year and Date: 2015-06-05