| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Tobacco contains many harmful substances. Cadmium(Cd) which is known as the cause of Itai-itai disease is also present in comparatively high concentration. Periodontal disease is an infectious disease caused by periodontal bacteria living in the oral cavity, however, the onset and progression of the disease are deeply inflenced by various habits and lifestyle choices, among which smoking is one of the most important risk facors. The objective of the present study was to examine the correlation Cd in tobacco and alvelar bone resorption occured in periodontal disease using both human osteoblasts and pre-osteoclasts in vitro. As a result, Cd had effected on cellular functions. These results suggested that smorker was high risk person to periodontal disease.
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