Basic approach to elucidation of flavor formation mechanism which contribute to super aged society
| Project/Area Number |
26463192
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小林 真之 日本大学, 歯学部, 教授 (00300830)
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| Co-Investigator(Renkei-kenkyūsha) |
MURAMOTO Kazuyo 明海大学, 歯学部, 教授 (10301798)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脳神経科学 / 光学計測 / 島皮質 / 味覚 / 嗅覚 / 風味 |
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| Outline of Final Research Achievements |
Patients having feeding/swallowing difficulty (dysphagia) have been increased with the advancement of an aging society. “Enjoy eating” is important not only for maintaining life but also for preserving quality of life and motivation for rehabilitation of dysphagia. The core of flavor is gustatory information and olfaction. However, it has been unclear how and where two kind of senses are integrated. To address this issue, we examined the spatiotemporal dynamics of excitatory propagation in cerebral cortex induced by simultaneous electrical stimulation of the chorda tympani nerve (CT) and main olfactory bulb (mOB). We performed in vivo optical imaging with a voltage sensitive dye. The primary sensory areas responded to each single stimulus. The simultaneous stimulation to mOB and CT increased the excitation in the AI, addition to response of each primary sensory cortices. This result suggest that partial of the gustatory and olfactory information was integrated in the AI.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Non-neuronal cardiac cholinergic system influences CNS via the vagus nerve to acquire a stress-refractory propensity.2016
Author(s)
Oikawa S, Kai Y, Tsuda M, Ohata H, Mano A, Mizoguchi N, Sugama S, Nemoto T, Suzuki K, Kurabayashi A, Muramoto K, Kaneda M, and Kakinuma Y.
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Journal Title
Clinical Science
Volume: 130(21)
Issue: 21
Pages: 1913-1928
DOI
Related Report
Peer Reviewed
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