Innate immune response in aged mice given fermented foods
| Project/Area Number |
26463195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
TAGUCHI Chieko 日本大学, 松戸歯学部, 助手(専任扱) (80434091)
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| Co-Investigator(Kenkyū-buntansha) |
小林 良喜 日本大学, 松戸歯学部, 助手(専任扱) (10609085)
有川 量崇 日本大学, 松戸歯学部, 准教授 (50318325)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 老齢マウス / 発酵食品 / 自然免疫機構 / 抗菌性ペプチド / 市販納豆 / 免疫応答 / 腸内細菌 / 短鎖脂肪酸 / 抗菌ペプチド |
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| Outline of Final Research Achievements |
The objective of this study was to detect any immunological responses that may be enhanced in aged or young mice by consuming fermented dietary products such as natto. When mice were administered natto, low levels of IgA and IgG were seen in both young and aged mice. However, inductions of murine β-defensin specific mRNA were detected in the gum of both young and aged mice fed natto. In addition, the intestinal flora showed an increase of Clostridium subcluster XIVa, and the presence of butyrate as a metabolic product was confirmed.
These results suggest that eating natto activates oral immunological responses and contributes to a healthy increase in beneficial gut flora.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] 口腔環境といびきの関連性 市川市(千葉県)における口腔内診査とアンケート調査結果2015
Author(s)
有川 量崇, 田口 千恵子, 鈴木 浩司, 石井 広志, 千葉 和成, 長谷川 勝, 内山 敏一, 小林 良喜, 伊藤 誠康, 竹内 麗理, 永岡 明記, 小椋 正之, 和田 康志, 那須 郁夫、
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Journal Title
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長濱文雄,田中 宏征, 内山 敏一, 有川 量崇, 田口 千恵子, 横田 容子, 牧村 英樹, 景山 万貴子, 藤田 光, 木本 統, 河野 善治, 福本 雅彦
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Journal Title
日本歯科人間ドック学会誌
Volume: 10
Pages: 27-33
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[Journal Article] Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss2015
Author(s)
Ujjal K.Bhawal, Hye-Jin Lee, Kazumune Arikawa, Michiharu Shimosaka, Masatoshi Suzuki, Toshizo Toyama, Takenori Sato, Ryota Kawamata, Chieko Taguchi, Noubushiro Hamada, Ikuo Nasu, Hirohisa Arakawa and Kou S
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Journal Title
International Journal of Oral-Medical Sciences
Volume: 7
Pages: 242-249
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Investigation about Welfare of Society for Special Needs of Dental Students2014
Author(s)
後藤田 宏也, 野本 たかと, 梅澤 幸司, 林 佐智代, 水野 貴誠, 葛西 一貴, 田口 千恵子, 大沢 聖子, 卯田 昭夫, 桑原 紀子, 牧村 英樹, 平塚 浩一, 三枝 禎, 笹井 啓史, 伊藤 孝訓, 河相 安彦, 那須 郁夫, 渋谷 鑛, 牧村 正治
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Volume: 40
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[Journal Article] 歯肉に限局した色素沈着2症例の検討2014
Author(s)
布施 恵, 遠藤弘康, 末光正昌, 田中宏征, 市村真奈, 田口千恵子, 有川量崇, 内山敏一, 續橋 治, 深津 晶, 久山佳代, 伊藤孝訓, 福本雅彦
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Journal Title
日本歯科人間ドック学会誌
Volume: 9
Pages: 45-49
Related Report
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