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The roles of CREBH in non-alcoholic fatty liver

Research Project

Project/Area Number 26500001
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionUniversity of Tsukuba

Principal Investigator

KOBAYASHI Kazuto  筑波大学, 医学医療系, 研究員 (30455935)

Co-Investigator(Kenkyū-buntansha) 中川 嘉  筑波大学, 国際統合睡眠医科学研究機構, 准教授 (80361351)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords非アルコール性脂肪肝 / 脂質代謝 / 生活習慣病 / 遺伝子発現
Outline of Final Research Achievements

In this study, we examined how CREBH is involved in lifestyle-related diseases, especially on the development and progression of nonalcoholic fatty liver. CREBH liver-specific KO (LKO) mouse using CRISPR/Cas9 system was successfully produced. The mouse exhibited a remarkable increase in blood lipids upon fasting. One of the causes is the increase of the transcription factor SREBPs which govern the expression of fatty acid and cholesterol synthesis genes. When LKO mice were fed with methionine choline deficient diet, which is a nonalcoholic fatty liver model, severe liver injury appeared in the early period. In this study, we have established a method for preparing new genetically modified mice, and clarified that deficiency of CREBH induces nonalcoholic fatty liver.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 Other

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Remarks (1 results)

  • [Journal Article] Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system.2016

    • Author(s)
      Nakagawa Y, Oikawa F, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, Song-iee H, Mizuno S. Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Suzuki H, Sone H, Takahashi S, Yamada N, Shimano H.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 27857-27857

    • DOI

      10.1038/srep27857

    • NAID

      120007135376

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Remarks] 筑波大学 医学医療系 内分泌代謝・糖尿病内科

    • URL

      http://www.u-tsukuba-endocrinology.jp/

    • Related Report
      2016 Annual Research Report 2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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