The effects of foods on epigenetic alterations in gastric carcinogenesis

• Project/Area Number: 26500004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: University of Fukui
• Principal Investigator: Suto Hiroyuki 福井大学, 学術研究院医学系部門, 客員准教授 (50345683)
• Co-Investigator(Kenkyū-buntansha): 中本 安成 福井大学, 学術研究院医学系部門, 教授 (40293352)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ヘリコバクター・ピロリ / 胃癌 / 胃炎 / 食品

Outline of Final Research Achievements

The aim of this study was to analyze the molecular mechanism of foods in gastric mucosal inflammation and gastric carcinogenesis. The extent of inflammation of the group with 10% salt food tended to be more severe than those of the group with regular diet and the group with catechin in Helicobacter pylori infection groups. However, no significant difference was recognized among these three groups in inflammatory cytokines and epigenetic alterations .

Research Products

• [Journal Article] 1.Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice. (2016)
  • Author(s): Ohno T, Ohtani M, Suto H, Ohta M, Imamura Y, Matsuda H, Hiramatsu K, Nemoto T, Nakamoto Y.
  • Journal Title: Oncol. Rep. Volume: 35 Issue: 6 Pages: 3241-3247
  • DOI: 10.3892/or.2016.4717
  • Peer Reviewed / Open Access
• [Journal Article] INS-GASマウスを用いたH.pylori感染胃発癌に対する性ホルモンの影響 (2016)
  • Author(s): 大谷昌弘、須藤弘之、中本安成
  • Journal Title: 日本ヘリコバクター学会誌 Volume: 17 Pages: 54-59
• [Journal Article] A case of Helicobacter pylori-negative intramucosal well-differentiated gastric adenocarcinoma with intestinal phenotype. (2015)
  • Author(s): Ozaki Y, Suto H, Nosaka T, Saito Y, Naito T, Takahashi K, Ofuji K, Matsuda H, Ohtani M, Hiramatsu K, Nemoto T, Imamura Y, Nakamoto Y.
  • Journal Title: Clin J Gastroenterol Volume: 8 Issue: 1 Pages: 18-21
  • DOI: 10.1007/s12328-014-0543-x
  • Peer Reviewed / Open Access
• [Presentation] Influence of antithrombotic drugs on gastric ulcer healing after endoscopic submucosal dissection. (2016)
  • Author(s): Takahashi K, Suto H, Nosaka T, Saito Y, Ozaki Y, Hayama R, Naito T, Ofuji K, Matsuda H, Ohtani M, Hiramatsu K, Nemoto T, Nakamoto Y
  • Organizer: DDW2016
  • Place of Presentation: San Diego, America
  • Int'l Joint Research
• [Presentation] 胃ESD症例におけるH.pylori感染診断，胃癌リスク診断の問題点 (2016)
  • Author(s): 高橋和人、須藤弘之、中本安成
  • Organizer: 第92回日本消化器内視鏡学会総会
  • Place of Presentation: 神戸国際展示場2号館（兵庫県神戸市）
• [Presentation] 胃ESD症例におけるH.pylori除菌後胃癌，未感染胃癌の臨床的特徴 (2015)
  • Author(s): 高橋和人、須藤弘之、中本安成ほか
  • Organizer: 第90回日本消化器内視鏡学会総会
  • Place of Presentation: 東京, グランドプリンスホテル新高輪
  • Year and Date: 2015-10-08
• [Presentation] 胃ESD後潰瘍治癒における薬剤の影響 (2015)
  • Author(s): 高橋和人、須藤弘之、中本安成
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台, 仙台国際センター
  • Year and Date: 2015-04-23
• [Presentation] H. pylori除菌後のディスペプシア症状、BMIの長期経過と胃粘膜萎縮との関連 (2014)
  • Author(s): 須藤弘之、加藤卓次、中本安成
  • Organizer: 第88回日本消化器内視鏡学会総会
  • Place of Presentation: 神戸，神戸国際展示場
  • Year and Date: 2014-10-24