Analysis of prevention of Alzheimer's disease based on underlying pathology
Project/Area Number |
26500006
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrated Nutrition Science
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Research Institution | Gifu University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 小胞体ストレス / フラボノイド / 認知症 / 記憶 / 想起 / ケルセチン / 記憶再生 / ATF4 / アルツハイマー病 / 食品成分 / 介入試験 / GADD34 / アルツハイマーモデルマウス / 食生活 |
Outline of Final Research Achievements |
Purpose of this study is to explore the action of quercetin and its target gene GADD34 for amyloid-beta production and impairment of learning and memory in Alzheimer’s disease (AD) model mice APP23. In addition, pilot study of intervention trial of quercetin high content onion to early stage AD patients was carried out. In this study, deterioration of memory impairment was delayed in AD mice feeding quercetin-containing food compared with AD mice feeding control food. The levels of GADD34 in the brains of AD mice feeding quercetin-containing food were higher than those of AD mice feeding control food. In addition, score of recall using HDS-R in early stage AD patients was significantly improved. These results suggest that quercetin may be promising functional food molecule to prevent memory impairment.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer's disease patients.2016
Author(s)
Nakagawa T, Itoh M, Ohta K, Hayashi Y, Hayakawa M, Yamada Y, Akanabe H, Chikaishi T, Nakagawa K, Itoh Y, Muro T, Yanagida D, Nakabayashi R, Mori T, Saito K, Ohzawa K, Suzuki C, Li S, Ueda M, Wang MX, Nishida E, Islam S, Tana, Kobori M, Inuzuka T.
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Journal Title
NeuroReport
Volume: 27
Issue: 9
Pages: 671-676
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Quercetin reduces eIF2α phosphorylation by GADD34 induction.2015
Author(s)
Hayakawa M, Itoh M, Ohta K, Li S, Ueda M, Wang MX, Nishida E, Islam S, Suzuki C, Ohzawa K, Kobori M, Inuzuka T, Nakagawa T.
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Journal Title
Neurobiology of Aging
Volume: 36
Issue: 9
Pages: 2509-2518
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.2014
Author(s)
Han J, Jung S, Jang J, Kam TI, Choi H, Kim BJ, Nah J, Jo DG, Nakagawa T, Nishimura M, Jung YK.
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Journal Title
Cellular and Molecular Life Sciences
Volume: 未定
Issue: 13
Pages: 2561-2576
DOI
Related Report
Peer Reviewed
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[Presentation] Motor neurons were degenerated in the Prune homolog 2 (Drosophila) (Prune2) gene deficient mice generated by CRISPR/Cas9 system.2015
Author(s)
Masanori Itoh, Emika Nishida, Saiful Islam, Shimo Li, Masatake Osawa, Dongsoo Lee, Huayue Chen , Masashi Ueda, Miao-xing Wang, Miki Hayakawa, Gen Ikeno, Koki Ichihashi, Kazuyuki Okamoto, Jun Tsutsumi, Toshiyuki Nakagawa
Organizer
45th ANNUAL MEETING Neuroscience
Place of Presentation
Chicago, USA
Year and Date
2015-11-17
Related Report
Int'l Joint Research
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