| Project/Area Number |
26500007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
SASAKI Masaya 滋賀医科大学, 医学部, 准教授 (40242979)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | エネルギー代謝 / 悪液質 / 肺がん / 消化器がん / 間接熱量測定 / 炎症性サイトカイン / 安静時エネルギー消費量 / 肺癌 |
|---|
| Outline of Final Research Achievements |
This study aimed to investigate the energy metabolism of patients with cancer using indirect calorimetry. Energy expenditure was increased in patients with advanced stage disease, and there were positive correlations between measured resting energy expenditure/body weight and interleukin-6 levels. However, there are no significant relationships between energy expenditure and TNF-α levels. There were significant relationships between body mass index and plasma leptin or acylated ghrelin levels. However, the level of appetite controlling hormones did not affect dietary intake. In addition, there was a negative correlation between plasma interleukin-6 levels and dietary intake, suggesting that interleukin-6 plays a role in reducing dietary intake. These results indicate that energy expenditure changes significantly with cancer stage. Thus, nutritional management that considers the changes in energy metabolism is important in patients with cancer.
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