The association of intestinal permeability with malnutrition in chronic kidney disease
| Project/Area Number |
26500011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 慢性腎臓病 / 栄養障害 / 腸管透過性 / 腸内細菌 / 炎症 / synbiotics / エンドトキシン |
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| Outline of Final Research Achievements |
The protein energy malnutrition in chronic kidney disease (CKD) is caused by inflammation, and it may be associated with increased intestinal permeability. The present study investigated the method for evaluating the intestinal permeability and the effect of prebiotics and probiotics on the intestinal permeability and inflammation in CKD rats. The results showed that the intestinal permeability can be examined using 4kD FITC-dextrin. Although the intestinal permeability increased with the progression of renal failure, the inflammation increased earlier than the intestinal permeability, suggesting the inflammation preceded the increased intestinal permeability. The administration of prebiotics and probiotics improved inflammation and renal function although the reason remained to be investigated.
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Report
(4 results)
Research Products
(9 results)
