Clarification of molecular mechanism of calcification and development to CKD nutritional therapy by correlation of bone and vascular
| Project/Area Number |
26500012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | University of Hyogo |
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Principal Investigator |
ITO MIKIKO 兵庫県立大学, 環境人間学部, 教授 (50314852)
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| Co-Investigator(Kenkyū-buntansha) |
坂上 元祥 兵庫県立大学, 環境人間学部, 教授 (20283913)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 血管石灰化 / 慢性腎蔵病 / 高リン血症 / リンチャネル / リン代謝異常 / 異所性石灰化 |
|---|
| Outline of Final Research Achievements |
Vascular calcification is a risk factor for cardiovascular events in chronic kidney disease (CKD) patients. In order to develop nutritional therapy for suppressing vascular calcification, we examined to clarify the phosphate regulation by bone-vessel interaction. In this study, we searched candidate molecule that function in phosphate regulation in both bone and vessel and then we analyzed the function in vitro and in vivo. The candidate molecule expression increased after differentiation of osteoclasts and calcification of vascular smooth muscle cells. In CKD model rat, the candidate molecule expressed at calcification area in vascular aorta. Thus, it was indicated that this molecule is likely to be involved in calcification. We will further research the function and relation with nutrition in the future, and will lead to the developing of nutrition therapy.
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Report
(4 results)
Research Products
(51 results)
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[Book] 化学同人2017
Author(s)
坂上元祥（平井みどり 他編）
Publisher
薬物治療学 代謝疾患の薬物治療
Related Report
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