The study of physiological action of free water in the small intestinal lumen involving controlling blood sugar

• Project/Area Number: 26500013
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Fukuoka Women's University
• Principal Investigator: Takahashi Toru 福岡女子大学, 人間環境学研究科, 准教授 (80324292)
• Co-Investigator(Kenkyū-buntansha): 安細 敏弘 九州歯科大学, 歯学部, 教授 (80244789) ; 小野塚 実 神奈川歯科大学, 歯学部, 名誉教授 (90084780) ; 徳永 美希 神奈川県立保健福祉大学, 保健福祉学部, 助教 (90610238)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 食物繊維 / 自由水 / 水の拡散係数 / 糖の拡散係数 / 粘度 / ベイジアンネットワーク / 分子の拡散 / 拡散係数 / 消化管 / 食後血糖 / 体外実験 / 水の拡散 / 糖の拡散 / 糖吸収

Outline of Final Research Achievements

Postprandial blood sugar levels have been explained by viscosity of intestinal contents. However, low viscosity fiber such as sunfiber and resistant starch reduced postprandial blood sugar increments. Our study showed postprandial blood glucose was depend on the diffusion rate of gluoce in the intestinal contents. The study focuced on effect of free water, diffusion of water and viscostiy on the diffusion of glucose in the intestinal contents. Causual effects was analyzed using Beysian network. Beysian network showed free water and diffusion of water decreased the diffusion of glucose in the intestinal contents.

Research Products

• [Int'l Joint Research] Durham University(英国)
• [Int'l Joint Research] Halberg Hospital and Research Institute(India)
• [Int'l Joint Research] Ottawa University(Canada)
• [Int'l Joint Research] School of Medicine, Pharmacy and Health/Duram University/Duram, UK(Wilson D.W.)
• [Int'l Joint Research] Halberg Hospital and Research Institute/Moradabad, India(Singh, R.B.)
• [Journal Article] Relationships between pathologic subjective halitosis, olfactory reference syndrome, and social anxiety in young Japanese women (2017)
  • Author(s): Miho Tsuruta, Toru Takahashi, Miki Tokunaga, Masanori Iwasaki, Shota Kataoka, Satoko Kakuta, Inho Soh, Shuji Awano, Hiromi Hirata, Masaharu Kagawa and Toshihiro Ansai
  • Journal Title: BMC Psychology Volume: 14 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s40359-017-0176-1
  • Peer Reviewed / Open Access
• [Journal Article] Therapy through Social Medicine: Cultivating Connections and Inspiring Solutions for Healthy Living, (2017)
  • Author(s): Douglas Wilson, Griffiths Keith, Buttar Harpal, Singh Ram, De Meester Fabien, Wilczynska Agnieszka, Toru Takahashi
  • Journal Title: AIMS Medical Science Volume: 4 Issue: 2 Pages: 131-150
  • DOI: 10.3934/medsci.2017.2.131
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Addition of Whey Peptides to a Carbohydrate-electrolyte Drink Enhances its Effect on the Early Treatment of Dehydration in Rats (2016)
  • Author(s): Kentaro Ito, Yuri Saito, Makoto Yamaguchi, Kinya Ashida, Taketo Yamaji, Hiroyuki Itoh, Toru Takahashi, Munehiro Oda,
  • Journal Title: Food Science and Technology Research Volume: 22 Pages: 623-629
  • Peer Reviewed
• [Journal Article] The Salivary IgA Flow Rate Is Increased by High Concentrations of Short-Chain Fatty Acids in the Cecum of Rats Ingesting Fructooligosaccharides. (2016)
  • Author(s): Yamamoto Y, Takahahi T, To M, Nakagawa Y, Hayashi T, Shimizu T, Kamata Y, Saruta J, Tsukinoki K.
  • Journal Title: Nutrients Volume: 8 Issue: 8 Pages: 500-500
  • DOI: 10.3390/nu8080500
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Addition of whey peptides to a carbohydrate-electrolyte drink enhances its effect on the early treatment of dehydration in rats (2016)
  • Author(s): Kentaro ITO, Yuri SAITO, Makoto YAMAGUCHI, Kinya ASHIDA, Taketo YAMAJI, Hiroyuki ITOH, Toru TAKAHASHI and Munehiro ODA
  • Journal Title: Food Sci. Technol. Res. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] 幼稚園児の弁当の食材を制御する要因解析と食材を変えるための方策. (2016)
  • Author(s): 堀内 理恵, 高橋 徹
  • Journal Title: 日本家政学会誌 Volume: 67 (2) Pages: 81-89
  • NAID: 130005126306
  • Peer Reviewed
• [Journal Article] Antioxidant Vitamins and Oxidative Stress in Chronic Heart Failure. (2015)
  • Author(s): R.B.Singh, K.Hristova, J.Fedacko, S.Singhal, S.Khan, D.W.Wilson, T.Takahashi, Z.Sharma,
  • Journal Title: World Heart Journal Volume: 7(4) Pages: 187-194
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diet and Atherosclerosis in Ancient Periods. (2015)
  • Author(s): G. Bjorklund, D. Wilson, F. De Meester, T. Takahashi, A. Wilczynska,
  • Journal Title: World Heart Journal Volume: 7(1) Pages: 51-61
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Intake of indigestible carbohydrates influences immunoglobulin A response and polymeric immunoglobulin receptor expression in the rat submandibular gland (2015)
  • Author(s): Yuko Yamamoto, Masahiro To, Takashi Hayashi, Tomoko Shimizu, Yohei Kamata, Juri Saruta, Toru Takahashi and Keiichi Tsukinoki
  • Journal Title: British Journal of Nutrition (in press) Volume: -
  • Peer Reviewed
• [Journal Article] A Modified Questionnaire to Find Out the Association of Depression with Increased Mortality, Among Urban Decedents, Dying Due to Various Causes. (2015)
  • Author(s): Agnieszka Wilczynska, Ram B Singh, M. A. Niaz, Toru Takahashi, Jan Fedacko, Fabien De Meester, Ratin Mondal, Douglas W Wilson.
  • Journal Title: The Open Nutraceuticals Journal Volume: 8 Pages: 5-15
  • Peer Reviewed / Open Access
• [Journal Article] Nutritional Modulators in Chronic Heart Failure (2014)
  • Author(s): Ram B. Singh, Krasimira Hristova, Galal El-Kilany, Toru Takahashi, Abdullah Shehab, Hilton Chaves, Douglas W. Wilson, Divya Rupini, Neelesh Gupta, Rajeev Gupta .
  • Journal Title: The Open Nutraceuticals Journal Volume: 8 Pages: 1-4
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Brain Derived Neurotrophic Factor, In Relation to Diet and Lifestyle Factors, for Prevention of Neuropsychiatric and Vascular Diseasesand Diabetes. (2014)
  • Author(s): Ram B. Singh, Toru Takahashi, Miki Tokunaga, Agnieszka Wilczynska, Chee J. Kim, Fabien De Meester, Teodora Handjieva-Darlenska, Sukhinder K. Cheema, Douglas W. Wilson, Branislav Milovanovic, Jan Fedacko, Krasimira Hristova , Hilton Chaves.
  • Journal Title: The Open Nutraceuticals Journal Volume: 7 Pages: 5-14
  • Peer Reviewed / Open Access
• [Journal Article] The "West" Has Made the Worst Model of Health and Pushing the World to the Slow Moving Disaster on Total Health. (2014)
  • Author(s): Toru Takahashi; R.B. Singh; Kuniaki Otsuka; R.R. Watson; D.W. Wilson; Fabien De Meester
  • Journal Title: World Heart Journal Volume: 6 (3) Pages: 1-4
  • Peer Reviewed / Open Access
• [Journal Article] Inflammatory mediators in chronic heart failure in North India. (2014)
  • Author(s): Fedacko J, Singh RB, Gupta A, Hristova K, Toda E, Kumar A, Saxena M, Baby A, Singh R, Takahashi T, Wilson DW.
  • Journal Title: Acta Cardiol Volume: 69 Pages: 391-398
  • Peer Reviewed / Open Access
• [Journal Article] Sofia declaration on transition of prevention strategies for cardiovascular disease and diabetes mellitus in developing countries: a statement from the International College of Cardiology and International College of Nutrition. (2014)
  • Author(s): K. Hristova, B D Dimitrov, SS Rastogi, F DeMeester, B Milovanovic, I Shiue, D Pella, H Chaves, R B Singh, T Takahashi, S Cheema, T K Basu, D Wilson, et al.
  • Journal Title: Nutrition Volume: 30 (9) Pages: 1085-1089
  • Peer Reviewed
• [Presentation] Association between bacterial fermentation in the large intestine and CVDs (2016)
  • Author(s): T Takahashi, M Tokunaga, DW Wilson, RB Singh
  • Organizer: 7th International Congress of Cardiology (ICC7)From Prevention to Intervention of Cardiovascular Diseases
  • Place of Presentation: カイロ、エジプト
  • Year and Date: 2016-10-29
  • Int'l Joint Research / Invited
• [Presentation] Functional foods for health: gut-brain axis and microbiota; food, environment and chronobiological interactions. (2016)
  • Author(s): Buttar H, Singh RB, Griffiths K, Takahashi T, Wilson DW, Hristova K, Wilczynska A and De Meester F.
  • Organizer: international conference on recent advances in food processing and Food Buisiness
  • Place of Presentation: Varanasi、インド
  • Year and Date: 2016-04-05
  • Int'l Joint Research / Invited
• [Presentation] Cardiovascular Diseases: Dietary Composition and Kinetics (2015)
  • Author(s): T. Takahashi, R.B. Singh, F. de Meester, D.W. Wilson,
  • Organizer: International Congress of Cardiology & Cardiovascular Imaging “ Diabetes and the Heart”
  • Place of Presentation: ドバイ
  • Year and Date: 2015-10-22
  • Int'l Joint Research / Invited
• [Presentation] Pectin decreases the postprandial blood glucose increment by decreasing free water in the intestinal contents. (2015)
  • Author(s): T. Takahashi, M. Niwa, K. Kubo, M. Machida,
  • Organizer: 12th European Nutrition Conference
  • Place of Presentation: ベルリン、ドイツ
  • Year and Date: 2015-10-20
  • Int'l Joint Research
• [Presentation] 煮干しだし揮発性成分水溶液とイノシン酸水溶液によって起こるうま味認知に塩分濃度が与える影響 (2014)
  • Author(s): 徳永美希、畔野佳央理、丹羽政美、久保金哉、平野好幸、小野塚実、高橋徹
  • Organizer: 第68回日本栄養・食糧学会
  • Place of Presentation: 札幌
  • Year and Date: 2014-09-13
• [Presentation] Effect of circadian restricted feeding on risk of obesity and cardiovascular disease. (2014)
  • Author(s): T. Takahashi, M.Tokunaga R. B. Singh
  • Organizer: 3rd international congress on Lipid Metabolism & Atherosclerosis, 13th September 2014.
  • Place of Presentation: Seoul
  • Year and Date: 2014-09-12
  • Invited
• [Presentation] 幼稚園給食の指導の検 (2014)
  • Author(s): 眞木優子，高橋徹，堀内理恵
  • Organizer: 第61回日本栄養改善学 会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-08-22
• [Presentation] 水の拡散係数、自由水含量および粘度がモデル消化管内容物中のグルコース拡散に与える影響（トピックス演題） (2014)
  • Author(s): 高橋徹,丹羽政美,谷村織江,堀内理恵,徳永美希
  • Organizer: 第68回日本栄養・食糧学会
  • Place of Presentation: 札幌
  • Year and Date: 2014-06-01
• [Book] Hypercholesterolemia: a disease of the brain, In Handbook of Cholesterol (Ed. R.R.Watson, F de Meester) (2015)
  • Author(s): R.B. Singh, M.A. Niaz, T. Takahashi, F. De Meester, A. Wilczynska, B. Saboo, A.Maheshwari, G. Cornelissen6, J. Singh and I.G. Telessy Chapter 1.
  • Publisher: Wageningen Academic publishers
• [Book] Chapter 8, The gut, brain, and heart connection, In: Cardiovascular health and chronomics (Ed. R.B.Singh), (2014)
  • Author(s): The gut, brain, and heart connection
  • Total Pages: 34
  • Publisher: Nova publisher