| Project/Area Number |
26500015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Jichi Medical University |
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Principal Investigator |
Soda Kuniyasu 自治医科大学, 医学部, 教授 (00221341)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 生活習慣病 / 老化 / アンチエイジング / ポリアミン / スペルミン / 遺伝子メチル化 / 遺伝子修飾 / 健康長寿食 / 抗炎症 / 異常メチル化 / 長寿 / 国際学会招聘 / 国内学会招聘 |
|---|
| Outline of Final Research Achievements |
Many experiments have shown that mammalian life-span extension cannot be attained by ingestion of the so-called antioxidants, such as polyphenols contained in healthy macrobiotic foods such as legumes and vegetables and in macrobiotic dietary pattern such as Mediterranean diet. We have reported that the polyamines (spermine and spermidine) contained in so-called healthy macrobiotic diet such as legumes, vegetables, mushrooms, fishes, and shellfishes, and the healthy macrobiotic diet pattern such as Mediterranean diet and the Japanese food extends life-span of mice. The purpose of the study is to unveil the biological background of polyamine-induced mammalian life-span extension. As a result, we found that, in addition to biological activities such as an anti-inflammation, an antioxidant action, a gene protective action, etc., polyamine inhibits abnormal gene methylation associated with aging and aging associated pathologies.
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