| Project/Area Number |
26500017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
長谷 都 聖マリアンナ医科大学, 医学部, 准教授 (20450611)
藤岡 仁美 聖マリアンナ医科大学, 医学部, 講師 (50410064)
萩原 裕子 聖マリアンナ医科大学, 医学部, 助教 (90468207)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 性差 / 環境 / 学習機能 / 海馬 / AMPA受容体サブユニット / シナプス / 記憶 / 高次機能 / 学習 / 性周期 / AMPA/NMDA比 / LTP / occlusion / 粉餌 / シェファー / CA1 / CA3 / パッチクランプ法 / 学習課題 / 栄養状況 / ラット |
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| Outline of Final Research Achievements |
Powded pellet diet enhanced hippocampus-related brain higher functions such as learning ability only in female rats. This molecular basis was revealed by electrophysiological and biochemical experiments that the functional changes in the AMPA receptor subunit composition which was associated with learning ability. Also, powdred pellet enhanced synaptic function in the hippocampus. These changes were related to estrogen.
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