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Influence of the chemical structure of dietary lipids on the bioavailability of coexistent food factors

Research Project

Project/Area Number 26500020
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionKindai University

Principal Investigator

MUROTA Kaeko  近畿大学, 理工学部, 准教授 (40294681)

Co-Investigator(Renkei-kenkyūsha) MATSUMURA Yasuki  京都大学, 大学院農学研究科, 教授 (50181756)
OHKUBO Takeshi  仙台白百合女子大学, 人間学部, 准教授 (40513172)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsリン脂質 / 消化 / リンパ輸送 / 脂溶性ビタミン / 小腸透過性 / DHA / Caco-2 / カロテノイド / ビタミンE / 吸収 / 小腸 / 細胞間透過性
Outline of Final Research Achievements

The objective of this study is to clarify the influence of the chemical structure of dietary lipids on the bioavailability of various food factors.
We investigated the intestinal absorption of docosahexaenoic acid (DHA) derived from phospholipid, triacylglycerol and free DHA using unanesthetized lymph-cannulated rats. Phospholipid administration resulted in a significantly higher level of DHA in the phospholipid fraction than the other two samples administrations in the lymph. DHA at the sn-2 position of phospholipids was less hydrolyzed by pancreatin than by purified phospholipase A2 in vitro.
Absorption of lipophilic vitamins was also examined. It is confirmed that digestive products from dietary lipids were important to enhance the vitamins absorption via enhancing the mixed micelle formation and the accessibility to the intestinal epithelium. Furthermore, lysolipids produced from dietary phospholipids were shown to affect the permeability of differentiated human Caco-2 monolayers.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015 2014

All Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] 食事性リン脂質の構成脂肪酸が腸管吸収過程における消化性に及ぼす影響2017

    • Author(s)
      室田佳恵子、平野明伽音、渡辺嘉、大久保剛
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都府京都市(京都女子大学)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] ナノ粒子化加工によるビタミンEの吸収促進機構の解明2016

    • Author(s)
      室田 佳恵子、大塚 芹、菅田 望、村上 陽子、伊佐治 知也、寺尾 純二、河田 照雄、松村 康生、大久保 剛
    • Organizer
      日本栄養・食糧学会第70回大会
    • Place of Presentation
      兵庫県西宮市(武庫川女子大学)
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effect of nanoparticle processing on vitamin E absorption in human intestinal Caco-2 cells and rats2015

    • Author(s)
      Kaeko Murota, Takeshi Ohkubo, Nozomi Sugata, Yoko Murakami, Rina Higashitani, Tomoya Isaji, Junji Terao, Teruo Kawada, Yasuki Matsumura
    • Organizer
      The 6th International Conference on Food Factors
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Digestion and absorption of phospholipids as a dietary source of docosahexaenoic acid in rats2015

    • Author(s)
      Kaeko Murota, Mika Takagi, Shun Kumamoto, Takeshi Ohkubo, Akira Tokumura
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      PACIFICO Yokohama, Yokohama, Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Caco-2細胞を用いた小腸上皮透過性に及ぼすリン脂質消化産物の影響評価2015

    • Author(s)
      室田佳恵子、熊本舜、福嶋伸之、徳村彰
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学(岡山県)
    • Year and Date
      2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] ラットおよびヒトCaco-2細胞を用いた小腸におけるリン脂質消化吸収過程の解析2014

    • Author(s)
      室田佳恵子、高木美佳、熊本舜、山川祥悟、岸野恵理佳、大久保剛、徳村彰
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      酪農学園大学(北海道)
    • Year and Date
      2014-05-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Caco-2細胞を用いた食品成分による細胞間透過性亢進に対するリゾホスファチジン酸の作用解明2014

    • Author(s)
      熊本舜、福嶋伸之、徳村彰、室田佳恵子
    • Organizer
      第68回日本栄養・食糧学会大会
    • Place of Presentation
      酪農学園大学(北海道)
    • Year and Date
      2014-05-31
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2020-01-20  

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