| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The objective of this study is to clarify the influence of the chemical structure of dietary lipids on the bioavailability of various food factors.
We investigated the intestinal absorption of docosahexaenoic acid (DHA) derived from phospholipid, triacylglycerol and free DHA using unanesthetized lymph-cannulated rats. Phospholipid administration resulted in a significantly higher level of DHA in the phospholipid fraction than the other two samples administrations in the lymph. DHA at the sn-2 position of phospholipids was less hydrolyzed by pancreatin than by purified phospholipase A2 in vitro.
Absorption of lipophilic vitamins was also examined. It is confirmed that digestive products from dietary lipids were important to enhance the vitamins absorption via enhancing the mixed micelle formation and the accessibility to the intestinal epithelium. Furthermore, lysolipids produced from dietary phospholipids were shown to affect the permeability of differentiated human Caco-2 monolayers.
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