Basic analysis on the effectiveness of polyphenols as preventive and therapeutic agents in stress related diseases
| Project/Area Number |
26500022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMAKI Ruka 西南女学院大学, 保健福祉学部, 准教授 (80389486)
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| Research Collaborator |
LI Xiaojia
YOSHINAGA Yukari
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ポリフェノール / カテコールアミン / チロシン水酸化酵素 / ストレス / アセチルコリン受容体 / catecholamine / polyphenol / tyrosine hydroxylase / acetylacholine receptor / Ca channel / catecholamine secretion / transporter / acetylcholine receptor / Na channel / Polyphenol / secretion / synthesis / channel |
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| Outline of Final Research Achievements |
The polyphenols that may be applicable as a prophylactic agent with a stress reduction effect or a remedy for mood disorders were selected in adrenal medullary cells. Apigenin, aurapten and ikarisoside A inhibited concentration-dependently inhibited the secretion of catecholamines induced by acetylcholine(ACh). These polyphenols inhibited Na influx and Ca influx induced by ACh in a concentration-dependent manner similar to that of catecholamine secretion. Apigenin and luteolin suppressed tyrosine hydroxylase (TH) activity. Icarisoside A also suppressed catecholamine synthesis and TH activity induced by ACh. The present findings suggest that apigenin and ikarisoside A inhibit acetylcholine-induced catecholamine secretion and synthesis through suppressing ion influx in the adrenal medulla. These polyphenols also may protect the hyperactive catecholamine system induced by strong stress or emotional excitation which evokes the secretion of ACh from the splanchnic nerves.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Ikarisoside A inhibits acetylcholine-induced catecholamine secretion and synthesis by suppressing nicotinic acetylcholine receptor-ion channels in cultured bovine adrenal medullary cells.2015
Author(s)
Li X, Toyohira Y., Horisita T., Satoh N., Takahashi K., Zhang H., Iinuma M.,Yoshinaga Y., Ueno S., Tsutsui M., Sata T., Yanagihara N.
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Journal Title
Naunyn-Schmiedeberg’s Arch Pharmacol
Volume: 388
Issue: 12
Pages: 1259-1269
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse.2014
Author(s)
Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Arakaki K, Kina-Tanada M, Kubota H, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Igarashi T, Ueno S, Matsushita M, Ishiuchi S, Masuzaki H, Ohya Y, Yanagihara N, Shimokawa H, Otsuji Y, Tamura M, Tsutsui M.
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Journal Title
J Mol Cell Cardiol.
Volume: 77
Pages: 29-41
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ｎｉｔｒｉｃ ｏｘｉｄｅ ｅｘｅｒｔｓ ｐｒｏｔｅｃｔｉｖｅ ｅｆｆｅｃｔｓ ａｇａｉｎｓｔ ｂｌｅｏｍｙｃｉｎ ｉｎｄｕｃｅｄ ｐｕｌｍｏｎａｒｙ ｆｉｂｒｏｓｉｓ ｉｎ ｍｉｃｅ2014
Author(s)
Noguchi S，Yatera K，Wang KY, Oda K, Akata K, Yamasaki K, Kawanami T, Ishimoto H, Toyohira Y, Shimokawa H, Yanagihara N, Tsutsui M, Mukae H
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Journal Title
Ｒｅｓｐｉｒａｔｏｒｙ ｒｅｓｅａｒｃｈ
Volume: 5
Issue: 1
Pages: 92-92
DOI
Related Report
Peer Reviewed / Open Access
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