| Project/Area Number |
26500022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMAKI Ruka 西南女学院大学, 保健福祉学部, 准教授 (80389486)
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| Research Collaborator |
LI Xiaojia
YOSHINAGA Yukari
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ポリフェノール / カテコールアミン / チロシン水酸化酵素 / ストレス / アセチルコリン受容体 / catecholamine / polyphenol / tyrosine hydroxylase / acetylacholine receptor / Ca channel / catecholamine secretion / transporter / acetylcholine receptor / Na channel / Polyphenol / secretion / synthesis / channel |
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| Outline of Final Research Achievements |
The polyphenols that may be applicable as a prophylactic agent with a stress reduction effect or a remedy for mood disorders were selected in adrenal medullary cells. Apigenin, aurapten and ikarisoside A inhibited concentration-dependently inhibited the secretion of catecholamines induced by acetylcholine(ACh). These polyphenols inhibited Na influx and Ca influx induced by ACh in a concentration-dependent manner similar to that of catecholamine secretion. Apigenin and luteolin suppressed tyrosine hydroxylase (TH) activity. Icarisoside A also suppressed catecholamine synthesis and TH activity induced by ACh. The present findings suggest that apigenin and ikarisoside A inhibit acetylcholine-induced catecholamine secretion and synthesis through suppressing ion influx in the adrenal medulla. These polyphenols also may protect the hyperactive catecholamine system induced by strong stress or emotional excitation which evokes the secretion of ACh from the splanchnic nerves.
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